| Literature DB >> 11286687 |
M F Neurath1, S Finotto, I Fuss, M Boirivant, P R Galle, W Strober.
Abstract
T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.Entities:
Mesh：
Year: 2001 PMID： 11286687 DOI： 10.1016/s1471-4906(00)01798-1
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687