BACKGROUND: The purpose of the present study was to evaluate the severity of and factors related to osteopenia in children with cerebral palsy (CP). METHODS: Bone mineral density (BMD), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), creatinine, parathyroid hormone (PTH) and 25-hydroxy vitamin D3 (25OHD3) concentrations were determined in 24 children with CP (15 ambulant, nine non-ambulant), aged between 10 months and 12 years (mean (+/-SD) 4.1+/-2.9 years). These vaules were compared with data obtained from a control group. RESULTS: Adjusted mean BMD values were lower in the patient group than in controls (P<0.05). However, there was no difference between BMD values of ambulant and non-ambulant patients. The Ca and P levels of the patient group were significantly higher than those of controls (P<0.05). CONCLUSIONS: The present study showed that BMD was decreased in all children with CP, but to a greater extent in non-ambulant children with CP, and immobilization is the major effective factor on bone mineralization.
BACKGROUND: The purpose of the present study was to evaluate the severity of and factors related to osteopenia in children with cerebral palsy (CP). METHODS: Bone mineral density (BMD), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), creatinine, parathyroid hormone (PTH) and 25-hydroxy vitamin D3 (25OHD3) concentrations were determined in 24 children with CP (15 ambulant, nine non-ambulant), aged between 10 months and 12 years (mean (+/-SD) 4.1+/-2.9 years). These vaules were compared with data obtained from a control group. RESULTS: Adjusted mean BMD values were lower in the patient group than in controls (P<0.05). However, there was no difference between BMD values of ambulant and non-ambulant patients. The Ca and P levels of the patient group were significantly higher than those of controls (P<0.05). CONCLUSIONS: The present study showed that BMD was decreased in all children with CP, but to a greater extent in non-ambulant children with CP, and immobilization is the major effective factor on bone mineralization.
Authors: Tishya A L Wren; David C Lee; Reiko Hara; Susan A Rethlefsen; Robert M Kay; Frederick J Dorey; Vicente Gilsanz Journal: J Pediatr Orthop Date: 2010 Oct-Nov Impact factor: 2.324
Authors: Jasreen Kular; Jennifer C Tickner; Nathan J Pavlos; Helena M Viola; Tamara Abel; Bay Sie Lim; Xiaohong Yang; Honghui Chen; Robert Cook; Livia C Hool; Ming Hao Zheng; Jiake Xu Journal: J Biol Chem Date: 2014-12-01 Impact factor: 5.157
Authors: Tishya Al Wren; David C Lee; Robert M Kay; Frederick J Dorey; Vicente Gilsanz Journal: Dev Med Child Neurol Date: 2010-12-17 Impact factor: 5.449