PURPOSE: To determine, using scanning laser polarimetry, whether or not the retinal nerve fiber layer (RNFL) is altered in dementia of the Alzheimer type (DAT). METHODS: Thirty individuals with mild to moderate DAT and 30 healthy age-matched controls participated in the study. Fundus images were acquired with a Nerve Fiber Analyzer. RNFL thickness measurements were obtained under an ellipse located 1.75 disc diameter from the optic nerve head (ONH) center. RESULTS: No differences in RNFL thickness were observed between DAT and healthy subjects. The regional distribution of RNFL thickness was similar between the two test groups, with the RNFL being thickest in the superior and inferior retinal segments relative to the nasal and temporal regions. CONCLUSIONS: Our data indicate that the RNFL is not altered in DAT, at least in the earlier stages of the disease.
PURPOSE: To determine, using scanning laser polarimetry, whether or not the retinal nerve fiber layer (RNFL) is altered in dementia of the Alzheimer type (DAT). METHODS: Thirty individuals with mild to moderate DAT and 30 healthy age-matched controls participated in the study. Fundus images were acquired with a Nerve Fiber Analyzer. RNFL thickness measurements were obtained under an ellipse located 1.75 disc diameter from the optic nerve head (ONH) center. RESULTS: No differences in RNFL thickness were observed between DAT and healthy subjects. The regional distribution of RNFL thickness was similar between the two test groups, with the RNFL being thickest in the superior and inferior retinal segments relative to the nasal and temporal regions. CONCLUSIONS: Our data indicate that the RNFL is not altered in DAT, at least in the earlier stages of the disease.
Authors: Fang Ko; Zaynah A Muthy; John Gallacher; Cathie Sudlow; Geraint Rees; Qi Yang; Pearse A Keane; Axel Petzold; Peng T Khaw; Charles Reisman; Nicholas G Strouthidis; Paul J Foster; Praveen J Patel Journal: JAMA Neurol Date: 2018-10-01 Impact factor: 18.302
Authors: Harald Hampel; Nicola Toschi; Claudio Babiloni; Filippo Baldacci; Keith L Black; Arun L W Bokde; René S Bun; Francesco Cacciola; Enrica Cavedo; Patrizia A Chiesa; Olivier Colliot; Cristina-Maria Coman; Bruno Dubois; Andrea Duggento; Stanley Durrleman; Maria-Teresa Ferretti; Nathalie George; Remy Genthon; Marie-Odile Habert; Karl Herholz; Yosef Koronyo; Maya Koronyo-Hamaoui; Foudil Lamari; Todd Langevin; Stéphane Lehéricy; Jean Lorenceau; Christian Neri; Robert Nisticò; Francis Nyasse-Messene; Craig Ritchie; Simone Rossi; Emiliano Santarnecchi; Olaf Sporns; Steven R Verdooner; Andrea Vergallo; Nicolas Villain; Erfan Younesi; Francesco Garaci; Simone Lista Journal: J Alzheimers Dis Date: 2018 Impact factor: 4.472
Authors: Shannon L Risacher; Darrell Wudunn; Susan M Pepin; Tamiko R MaGee; Brenna C McDonald; Laura A Flashman; Heather A Wishart; Heather S Pixley; Laura A Rabin; Nadia Paré; Jessica J Englert; Eben Schwartz; Joshua R Curtain; John D West; Darren P O'Neill; Robert B Santulli; Richard W Newman; Andrew J Saykin Journal: Neurobiol Aging Date: 2012-10-18 Impact factor: 4.673
Authors: Elena Salobrar-Garcia; Irene Hoyas; Mercedes Leal; Rosa de Hoz; Blanca Rojas; Ana I Ramirez; Juan J Salazar; Raquel Yubero; Pedro Gil; Alberto Triviño; José M Ramirez Journal: Biomed Res Int Date: 2015-10-18 Impact factor: 3.411