Literature DB >> 11282303

Alpha4 integrins in cardiovascular development and diseases.

S Liu1, D M Rose, J Han, M H Ginsberg.   

Abstract

Alpha4 integrins (alpha4beta1 and alpha4beta7) have a restricted distribution pattern and are critical for the development and diseases of the cardiovascular system. alpha4 integrins support unique biological properties such as promoting cell migration and inhibiting cell spreading and focal adhesion formation. We have found that the alpha4 integrin subunit directly and tightly binds to a signaling adapter molecule, paxillin, and disruption of the alpha4-paxillin interaction interferes with many of alpha4-dependent biological functions. Consequently, the interaction of alpha4 integrins with paxillin may play an important role in regulating alpha4-mediated functions. This review focuses on what we have known about the alpha4-paxillin interaction and discusses the possible mechanism of regulation for this interaction.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11282303     DOI： 10.1016/s1050-1738(00)00073-6

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  12 in total

1.  EMILIN-1 deficiency induces elastogenesis and vascular cell defects.

Authors:  Miriam Zanetti; Paola Braghetta; Patrizia Sabatelli; Isabella Mura; Roberto Doliana; Alfonso Colombatti; Dino Volpin; Paolo Bonaldo; Giorgio M Bressan
Journal:  Mol Cell Biol       Date:  2004-01       Impact factor: 4.272

Review 2.  The role of integrins in the trabecular meshwork.

Authors:  Debjani Gagen; Jennifer A Faralli; Mark S Filla; Donna M Peters
Journal:  J Ocul Pharmacol Ther       Date:  2013-11-23       Impact factor: 2.671

3.  Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin.

Authors:  Colleen Ring; Mark H Ginsberg; Jacob Haling; Ann Marie Pendergast
Journal:  Proc Natl Acad Sci U S A       Date:  2010-12-20       Impact factor: 11.205

Review 4.  Progenitor cell mobilization and recruitment: SDF-1, CXCR4, α4-integrin, and c-kit.

Authors:  Min Cheng; Gangjian Qin
Journal:  Prog Mol Biol Transl Sci       Date:  2012       Impact factor: 3.622

5.  Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.

Authors:  Young-Min Hyun; Hung-Li Chung; James L McGrath; Richard E Waugh; Minsoo Kim
Journal:  J Immunol       Date:  2009-07-01       Impact factor: 5.422

6.  Oxygen-Dependent Gene Expression in Development and Cancer: Lessons Learned from the Wilms' Tumor Gene, WT1.

Authors:  Holger Scholz; Karin M Kirschner
Journal:  Front Mol Neurosci       Date:  2011-02-24       Impact factor: 5.639

7.  Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization.

Authors:  Gangjian Qin; Masaaki Ii; Marcy Silver; Andrea Wecker; Evelyn Bord; Hong Ma; Mary Gavin; David A Goukassian; Young-sup Yoon; Thalia Papayannopoulou; Takayuki Asahara; Marianne Kearney; Tina Thorne; Cynthia Curry; Liz Eaton; Lindsay Heyd; Deepika Dinesh; Raj Kishore; Yan Zhu; Douglas W Losordo
Journal:  J Exp Med       Date:  2006-01-09       Impact factor: 14.307

8.  Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCN-low Neuroblastoma.

Authors:  Shanique A Young; Katelyn E McCabe; Alena Bartakova; Joe Delaney; Donald P Pizzo; Robert O Newbury; Judith A Varner; David D Schlaepfer; Dwayne G Stupack
Journal:  PLoS One       Date:  2015-05-14       Impact factor: 3.240

9.  Rosuvastatin enhances angiogenesis via eNOS-dependent mobilization of endothelial progenitor cells.

Authors:  Junlan Zhou; Min Cheng; Yu-Hua Liao; Yu Hu; Min Wu; Qing Wang; Bo Qin; Hong Wang; Yan Zhu; Xiu-Mei Gao; David Goukassian; Ting C Zhao; Yao-Liang Tang; Raj Kishore; Gangjian Qin
Journal:  PLoS One       Date:  2013-05-21       Impact factor: 3.240

10.  Magnetic Resonance Imaging of Atherosclerotic Plaque at Clinically Relevant Field Strengths (1T) by Targeting the Integrin α4β1.

Authors:  Darren G Woodside; Eric A Tanifum; Ketan B Ghaghada; Ronald J Biediger; Amy R Caivano; Zbigniew A Starosolski; Sayadeth Khounlo; Saakshi Bhayana; Shahrzad Abbasi; John W Craft; David S Maxwell; Chandreshkumar Patel; Igor V Stupin; Deenadayalan Bakthavatsalam; Robert V Market; James T Willerson; Richard A F Dixon; Peter Vanderslice; Ananth V Annapragada
Journal:  Sci Rep       Date:  2018-02-27       Impact factor: 4.379
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.