Literature DB >> 11282194

Mixed immune response induced in rodents by two naked DNA genes coding for mycobacterial glycosylated proteins.

A Garapin1, L Ma, P Pescher, M Lagranderie, G Marchal.   

Abstract

Two genes of Mycobacterium tuberculosis, apa (Rv1860) and pro (Rv1796), coding for two glycosylated excreted proteins have been injected to mice and guinea pigs. They produce an extended immunological response of Th1 and Th2 types. Despite the fact that mycobacterial glycosylation is necessary for a high level of delayed-type hypersensitivity (DTH) reaction, plasmids bearing each of the two genes induced an elevated level of DTH sensitization. An inverse relation between the CpG-N hexamer cluster frequency and the protective effect of injected genes is described. A comparison of the strength of several eukaryotic promoters based on the diameter of the DTH reaction shows that CMVIE followed by the ubiquitin promoter are the most efficient among those tested. A significant protective effect (0.7 log unit CFU) in mice was found for the apa gene while the pro gene had no effect.

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Year:  2001        PMID： 11282194     DOI： 10.1016/s0264-410x(01)00012-3

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  8 in total

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Journal:  Infect Immun       Date:  2003-04       Impact factor: 3.441

2.  A single dose of a DNA vaccine encoding apa coencapsulated with 6,6'-trehalose dimycolate in microspheres confers long-term protection against tuberculosis in Mycobacterium bovis BCG-primed mice.

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Journal:  Clin Vaccine Immunol       Date:  2013-06-05

3.  A DNA prime-Mycobacterium bovis BCG boost vaccination strategy for cattle induces protection against bovine tuberculosis.

Authors:  Margot A Skinner; Bryce M Buddle; D Neil Wedlock; Denise Keen; Geoffrey W de Lisle; Ricardo E Tascon; Jose Candido Ferraz; Douglas B Lowrie; Paul J Cockle; H Martin Vordermeier; R Glyn Hewinson
Journal:  Infect Immun       Date:  2003-09       Impact factor: 3.441

4.  A DNA fusion vaccine induces bactericidal antibodies to a peptide epitope from the PorA porin of Neisseria meningitidis.

Authors:  Delin Zhu; Jeannette N Williams; Jason Rice; Freda K Stevenson; John E Heckels; Myron Christodoulides
Journal:  Infect Immun       Date:  2007-10-29       Impact factor: 3.441

5.  Boosting BCG-primed responses with a subunit Apa vaccine during the waning phase improves immunity and imparts protection against Mycobacterium tuberculosis.

Authors:  Subhadra Nandakumar; Sunil Kannanganat; Karen M Dobos; Megan Lucas; John S Spencer; Rama Rao Amara; Bonnie B Plikaytis; James E Posey; Suraj B Sable
Journal:  Sci Rep       Date:  2016-05-13       Impact factor: 4.379

Review 6.  The Humoral Immune Response to BCG Vaccination.

Authors:  Rachel Tanner; Bernardo Villarreal-Ramos; H Martin Vordermeier; Helen McShane
Journal:  Front Immunol       Date:  2019-06-11       Impact factor: 7.561

7.  DNA vaccines: improving expression of antigens.

Authors:  Helen S Garmory; Katherine A Brown; Richard W Titball
Journal:  Genet Vaccines Ther       Date:  2003-09-16

8.  Transgenic Nicotiana tabacum seeds expressing the Mycobacterium tuberculosis Alanine- and Proline-rich antigen.

Authors:  Diego G Módolo; Cynthia S Horn; José S M Soares; José A Yunes; Leila M Lima; Sylvia M de Sousa; Marcelo Menossi
Journal:  AMB Express       Date:  2018-10-31       Impact factor: 3.298
  8 in total

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