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Literature DB >> 11282167

Enhanced expression of fractalkine in HIV-1 associated dementia.

C F Pereira¹, J Middel, G Jansen, J Verhoef, H S Nottet.

Abstract

The CX(3)C chemokine fractalkine was found to be up-regulated in the brain during inflammatory processes. In this study, we tried to assess the role of fractalkine in HIV-1-associated dementia. Fractalkine expression is up-regulated in the brains of AIDS patients with HAD. Fractalkine immunoreactivity was mainly detected in astrocytes. In addition, fractalkine expression was found to be up-regulated in cocultures of astrocytes and HIV-infected macrophages. This up-regulation was dependent on cell-cell contact. We propose that fractalkine produced during interactions between astrocytes and HIV-infected macrophages plays a role in HAD by regulating the trafficking of monocytic cells in the brain parenchyma.

Entities: Disease Gene Species

Mesh：

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Year: 2001 PMID： 11282167 DOI： 10.1016/s0165-5728(01)00262-4

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

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Cited

28 in total

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Journal: Neurochem Res Date: 2004-05 Impact factor: 3.996

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3. WIN55,212-2 inhibits production of CX3CL1 by human astrocytes: involvement of p38 MAP kinase.

Authors: W S Sheng; S Hu; H T Ni; R B Rock; P K Peterson
Journal: J Neuroimmune Pharmacol Date: 2009-02-12 Impact factor: 4.147

Review 4. Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia.

Authors: R Cotter; C Williams; L Ryan; David Erichsen; A Lopez; H Peng; J Zheng
Journal: J Neurovirol Date: 2002-12 Impact factor: 2.643

5. Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.

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Journal: J Neurosci Date: 2019-08-30 Impact factor: 6.167

6. Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis.

Authors: Coryse St Hillaire; Diana Vargas; Carlos A Pardo; Dan Gincel; Jacquelyn Mann; Jeffrey D Rothstein; Justin C McArthur; Katherine Conant
Journal: J Neurovirol Date: 2005-12 Impact factor: 2.643

Enhanced expression of fractalkine in HIV-1 associated dementia.

Review 1. Chemokines and glial cells: a complex network in the central nervous system.

2. Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain.

3. WIN55,212-2 inhibits production of CX3CL1 by human astrocytes: involvement of p38 MAP kinase.

Review 4. Fractalkine (CX3CL1) and brain inflammation: Implications for HIV-1-associated dementia.

5. Microglia Mediate HIV-1 gp120-Induced Synaptic Degeneration in Spinal Pain Neural Circuits.

6. Aquaporin 4 is increased in association with human immunodeficiency virus dementia: implications for disease pathogenesis.

7. Contribution of CNS cells in NeuroAIDS.

Review 8. CNS inflammation and macrophage/microglial biology associated with HIV-1 infection.

Review 9. Astrocytes: Integrative Regulators of Neuroinflammation in Stroke and Other Neurological Diseases.

10. Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia.