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Literature DB >> 11281170

Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum.

K Satoh¹, T Hayakawa, Y Kase, A Ishige, H Sasaki, S Nishikawa, S Kurosawa, K Yakabi, T Nakamura.

Abstract

The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum. TJ-100 induced contractions accompanied by autonomous contraction at a concentration of more than 3 x 10(-4) g/ml in a dose-related manner. The TJ-100-induced ileal contraction was suppressed by atropine and tetrodotoxin, but not by hexamethonium. This effect was partially suppressed in the presence of high concentrations of ICS 205-930, a serotonin 4 (5-HT4) receptor antagonist. In addition, TJ-100 showed an acetylcholine (ACh)-releasing action in the smooth muscle tissues of ileum. These results suggest that contractile response induced by TJ-100 is partially mediated by ACh released from the cholinergic nerve endings and that 5-HT4 receptors would be involved in the effect of TJ-100.

Entities: Chemical Disease Species

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Year: 2001 PMID： 11281170 DOI： 10.1023/a:1005636412287

Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199

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