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Literature DB >> 11280928

Cowpea mosaic virus as a vaccine carrier of heterologous antigens.

Abstract

The plant virus, cowpea mosaic virus (CPMV), has been developed as an expression and presentation system to display antigenic epitopes derived from a number of vaccine targets including infectious disease agents and tumors. These chimeric virus particles (CVPs) could represent a cost-effective and safe alternative to live replicating virus and bacterial vaccines. A number of CVPs have now been generated and their immunogenicity examined in a number of animal species. This review details the humoral and cellular immune responses generated by these CVPs following both parenteral and mucosal delivery and highlights the potential of CVPs to elicit protective immunity from both viral and bacterial infection.

Entities: Disease Species

Mesh：

Substances：

Year: 2001 PMID： 11280928 DOI： 10.1385/MB:17:1:15

Source DB: PubMed Journal: Mol Biotechnol ISSN： 1073-6085 Impact factor: 2.695

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Authors: Jamie P Phelps; Nghiep Dang; Lada Rasochova
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Journal: Mol Biotechnol Date: 2014-12 Impact factor: 2.695