Literature DB >> 11278251

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

T Ebisawa1, M Fukuchi, G Murakami, T Chiba, K Tanaka, T Imamura, K Miyazono.   

Abstract

Smad7 is an inhibitory Smad that acts as a negative regulator of signaling by the transforming growth factor-beta (TGF-beta) superfamily proteins. Smad7 is induced by TGF-beta, stably interacts with activated TGF-beta type I receptor (TbetaR-I), and interferes with the phosphorylation of receptor-regulated Smads. Here we show that Smurf1, an E3 ubiquitin ligase for bone morphogenetic protein-specific Smads, also interacts with Smad7 and induces Smad7 ubiquitination and translocation into the cytoplasm. In addition, Smurf1 associates with TbetaR-I via Smad7, with subsequent enhancement of turnover of TbetaR-I and Smad7. These results thus reveal a novel function of Smad7, i.e. induction of degradation of TbetaR-I through recruitment of an E3 ligase to the receptor.

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Year:  2001        PMID： 11278251     DOI： 10.1074/jbc.C100008200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  285 in total

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Review 2.  Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance.

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Journal:  J Biol Chem       Date:  2012-04-02       Impact factor: 5.157

Review 4.  The role of the ubiquitin-proteasome system in kidney diseases.

Authors:  Hirotaka Fukasawa
Journal:  Clin Exp Nephrol       Date:  2012-06-09       Impact factor: 2.801

5.  Smad7 restricts melanoma invasion by restoring N-cadherin expression and establishing heterotypic cell-cell interactions in vivo.

Authors:  Kyle A DiVito; Valerie A Trabosh; You-Shin Chen; Yu Chen; Chris Albanese; Delphine Javelaud; Alain Mauviel; Cynthia M Simbulan-Rosenthal; Dean S Rosenthal
Journal:  Pigment Cell Melanoma Res       Date:  2010-08-25       Impact factor: 4.693

6.  Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

Authors:  Yuto Kamiya; Kohei Miyazono; Keiji Miyazawa
Journal:  J Biol Chem       Date:  2010-07-27       Impact factor: 5.157

7.  Ubiquitination-dependent regulation of signaling receptors in cancer.

Authors:  Wei-Chun Huangfu; Serge Y Fuchs
Journal:  Genes Cancer       Date:  2010-07

8.  Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression.

Authors:  Zhibo Gai; Gengyin Zhou; Ting Gui; Shunji Itoh; Kosuke Oikawa; Kohsaku Uetani; Yasuteru Muragaki
Journal:  J Am Soc Nephrol       Date:  2010-05-27       Impact factor: 10.121

9.  A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor.

Authors:  Mun Chun Chan; Peter H Nguyen; Brandi N Davis; Nobumichi Ohoka; Hidetoshi Hayashi; Keyong Du; Giorgio Lagna; Akiko Hata
Journal:  Mol Cell Biol       Date:  2007-06-18       Impact factor: 4.272

10.  Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts.

Authors:  Taihao Quan; Tianyuan He; John J Voorhees; Gary J Fisher
Journal:  J Biol Chem       Date:  2004-12-03       Impact factor: 5.157
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