| Literature DB >> 11278047 |
M Medou1, G Priem, L Rocheblave, G Pepe, M Meyer, J C Chermann, J L Kraus.
Abstract
A series of new anti-HIV derivatives containing a novel alpha-thiophenoxyhydroxyethylamide core have been synthesized, using S-phenylbenzenethiosulfonate as the thiosulfenylating reagent. Some of the new synthesized compounds (1a, 1c, 1g, 1i, 1j and 1l) inhibited HIV replication in cell culture assays (syncytia formation) with effective concentrations (EC(50)) ranging from 0.1-1 microM. Incorporation of thiophenoxy substitution within various pseudomimetic peptide backbones provided a series of highly potent HIV inhibitors.Entities:
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Year: 1999 PMID： 11278047 DOI： 10.1016/s0223-5234(00)80031-8
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514