| Literature DB >> 11277780 |
L Belvisi1, A Bernardi, A Checchia, L Manzoni, D Potenza, C Scolastico, M Castorina, A Cupelli, G Giannini, P Carminati, C Pisano.
Abstract
[structure: see text]. A small library of cyclic RGD pseudopentapeptides incorporating stereoisomeric 6,5- and 7,5-fused bicyclic lactams was synthesized with the aim of developing active and selective integrin antagonists. The solid-phase synthesis and activity of these RGD derivatives is described. The approach led to two of the most active known inhibitors of alpha(V)beta3 receptor.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11277780
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005