Literature DB >> 11277756

Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita.

N Takada1, M Watanabe, A Yamada, K Suenaga, K Yamada, K Ueda, D Uemura.   

Abstract

Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

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Year:  2001        PMID： 11277756     DOI： 10.1021/np0003490

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

1.  Manadodioxans A-E: polyketide endoperoxides from the marine sponge Plakortis bergquistae.

Authors:  Masaki Gushiken; Ippei Kagiyama; Hikaru Kato; Toshiyuki Kuwana; Fitje Losung; Remy E P Mangindaan; Nicole J de Voogd; Sachiko Tsukamoto
Journal:  J Nat Med       Date:  2015-05-26       Impact factor: 2.343

2.  Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium.

Authors:  Jilin Zhou; Young Pyo Jang; So Ra Kim; Janet R Sparrow
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-23       Impact factor: 11.205

3.  Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.

Authors:  Jiao Li; Cui Li; Raffaele Riccio; Gianluigi Lauro; Giuseppe Bifulco; Tie-Jun Li; Hua Tang; Chun-Lin Zhuang; Hao Ma; Peng Sun; Wen Zhang
Journal:  Mar Drugs       Date:  2017-05-03       Impact factor: 5.118

4.  Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.

Authors:  P Zhu; B M K Tong; R Wang; J P Chen; S Foo; H C Chong; X L Wang; G Y Ang; S Chiba; N S Tan
Journal:  Cell Death Dis       Date:  2013-03-21       Impact factor: 8.469
  4 in total

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