Literature DB >> 11277518

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.

S J Conway1, J C Miller, P A Howson, B P Clark, D E Jane.   

Abstract

The syntheses of a range of ring and alpha-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.

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Year:  2001        PMID： 11277518     DOI： 10.1016/s0960-894x(01)00052-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Independent presynaptic and postsynaptic mechanisms regulate endocannabinoid signaling at multiple synapses in the ventral tegmental area.

Authors:  Arthur C Riegel; Carl R Lupica
Journal:  J Neurosci       Date:  2004-12-08       Impact factor: 6.167

2.  A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.

Authors:  Jonathan P Saxe; Hao Wu; Theresa K Kelly; Michael E Phelps; Yi E Sun; Harley I Kornblum; Jing Huang
Journal:  Chem Biol       Date:  2007-09

3.  Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.

Authors:  Jacqueline C Miller; Patrick A Howson; Stuart J Conway; Richard V Williams; Barry P Clark; David E Jane
Journal:  Br J Pharmacol       Date:  2003-08       Impact factor: 8.739
  3 in total

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