Literature DB >> 11277517

The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin.

P J Murray1, M Kranz, M Ladlow, S Taylor, F Berst, A B Holmes, K N Keavey, A Jaxa-Chamiec, P W Seale, P Stead, R J Upton, S L Croft, W Clegg, M R Elsegood.   

Abstract

A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11277517     DOI： 10.1016/s0960-894x(01)00049-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.

Authors:  Ana Montero; John M Beierle; Christian A Olsen; M Reza Ghadiri
Journal:  J Am Chem Soc       Date:  2009-03-04       Impact factor: 15.419

2.  Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

Authors:  W Seth Horne; Christian A Olsen; John M Beierle; Ana Montero; M Reza Ghadiri
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

3.  Histone acetylation and methylation at sites initiating divergent polycistronic transcription in Trypanosoma cruzi.

Authors:  Patricia Respuela; Marcela Ferella; Alvaro Rada-Iglesias; Lena Aslund
Journal:  J Biol Chem       Date:  2008-04-09       Impact factor: 5.157

4.  Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.

Authors:  Jessica A Engel; Amy J Jones; Vicky M Avery; Subathdrage D M Sumanadasa; Susanna S Ng; David P Fairlie; Tina Skinner-Adams; Katherine T Andrews
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2015-06-20       Impact factor: 4.077

5.  Comparative effects of histone deacetylases inhibitors and resveratrol on Trypanosoma cruzi replication, differentiation, infectivity and gene expression.

Authors:  Vanina A Campo
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2016-12-21       Impact factor: 4.077

Review 6.  Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in schistosomiasis-induced liver fibrosis.

Authors:  Felipe Leite de Oliveira; Katia Carneiro; José Marques Brito; Mariana Cabanel; Jonathas Xavier Pereira; Ligia de Almeida Paiva; Wingkin Syn; Neil C Henderson; Marcia Cury El-Cheikh
Journal:  PLoS Negl Trop Dis       Date:  2017-02-23

Review 7.  Lysine acetylation: elucidating the components of an emerging global signaling pathway in trypanosomes.

Authors:  Victoria Lucia Alonso; Esteban Carlos Serra
Journal:  J Biomed Biotechnol       Date:  2012-10-03
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.