Literature DB >> 11277516

Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin.

S K Sharma1, A T Morrissey, G G Miller, W H Gmeiner, J W Lown.   

Abstract

The design and synthesis of the lipophilic (9) and fluorescent (10) conjugates of a structural analogue of distamycin and their in vitro cellular localization studies are reported. Confocal laser scanning microscopy (CLSM) indicates that 10 rapidly enters human ovarian adenocarcinoma (SKOV-3) cells with principal uptake in mitochondria and uniform cytoplasmic distribution.

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Year:  2001        PMID： 11277516     DOI： 10.1016/s0960-894x(01)00064-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Minor groove binding compounds that jump a gc base pair and bind to adjacent AT base pair sites.

Authors:  Maryam Rahimian; Arvind Kumar; Martial Say; Stanislav A Bakunov; David W Boykin; Richard R Tidwell; W David Wilson
Journal:  Biochemistry       Date:  2009-02-24       Impact factor: 3.162

Review 2.  Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer.

Authors:  Hiroki Nagase; Takayoshi Watanabe; Nobuko Koshikawa; Seigi Yamamoto; Keizo Takenaga; Jason Lin
Journal:  Cancer Sci       Date:  2021-10-04       Impact factor: 6.716

3.  Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.

Authors:  Zena A Al-Mudaris; Aman S A Majid; Dan Ji; Ban A Al-Mudarris; Shih-Hsun Chen; Po-Huang Liang; Hasnah Osman; Shah Kamal Khan Jamal Din; Amin M S Abdul Majid
Journal:  PLoS One       Date:  2013-11-15       Impact factor: 3.240
  3 in total

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