Literature DB >> 11277513

2,4-Thiazolidinediones as potent and selective human beta3 agonists.

B Hu1, J Ellingboe, I Gunawan, S Han, E Largis, Z Li, M Malamas, R Mulvey, A Oliphant, F W Sum, J Tillett, V Wong.   

Abstract

Methylsulfonamide substituted 2,4-thiazolidinedione 22c is a potent (EC50=0.01 microM, IA=1.19) and selective (more than 110-fold over beta1 and beta2 agonist activity) beta3 agonist. This compound has also been proven to be active and selective in an in vivo mode.

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Year:  2001        PMID： 11277513     DOI： 10.1016/s0960-894x(01)00063-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Comparative 3D QSAR study on β(1)-, β(2)-, and β(3)-adrenoceptor agonists.

Authors:  P Senthil Kumar; Prasad V Bharatam
Journal:  Med Chem Res       Date:  2009-10-31       Impact factor: 1.965

2.  Effective Procedure for Selective Ammonolysis of Monosubstituted Oxiranes: Application to E7389 Synthesis.

Authors:  Yosuke Kaburagi; Yoshito Kishi
Journal:  Tetrahedron Lett       Date:  2007-12       Impact factor: 2.415

3.  N-(2,5-Dimethoxy-phen-yl)-4-nitro-benzene-sulfonamide.

Authors:  Guo-Yao Zhang; Shan Qian; Xiao-Cen Li; Yong Wu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-22

4.  2-Nitro-p-phenyl-ene dibenzene-sulfonate.

Authors:  Zongwei Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-30

5.  4-Hydr-oxy-3-nitro-phenyl penta-noate.

Authors:  Hongxiang Yang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-01-30

6.  Synthesis of enantiopure 1,2-azido and 1,2-amino alcohols via regio- and stereoselective ring-opening of enantiopure epoxides by sodium azide in hot water.

Authors:  Hai-Yang Wang; Kun Huang; Melvin De Jesús; Sandraliz Espinosa; Luis E Piñero-Santiago; Charles L Barnes; Margarita Ortiz-Marciales
Journal:  Tetrahedron Asymmetry       Date:  2016-02-15

7.  3-Hydr-oxy-4-nitro-phenyl acetate.

Authors:  Chao Liu; Chunqing Cheng; Xiujie Ji
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-12-10

8.  2-Nitro-p-phenyl-ene bis-(toluene-sulfonate).

Authors:  Xiujie Ji; Bowen Cheng; Jun Song; Chao Liu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-08-23

Review 9.  Recent pharmacological developments on rhodanines and 2,4-thiazolidinediones.

Authors:  Ravinder Singh Bhatti; Sakshi Shah; Pawan Krishan; Jagir S Sandhu
Journal:  Int J Med Chem       Date:  2013-05-02
  9 in total

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