Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants.

Literature DB >> 1127728

Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants.

Abstract

A phytochemical investigation to identify inducers of increased aryl hydrocarbon hydroxylase (AHH) activity from three cruciferous vegetables, Brussels sprouts, cabbage, and cauliflower, resulted in the identification of indole-3-acetonitrile, indole-3-carbinol, and 3,3'-diindolylmethane as naturally occurring inducers. These compounds are produced during the hydrolysis of indolyl-methyl glucosinolate by the plant enzyme myrosinase.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1975 PMID： 1127728

Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506

Keyword Cloud
Cited

40 in total

Review 1. Dietary effects on drug metabolism and transport.

Authors: Robert Z Harris; Graham R Jang; Shirley Tsunoda
Journal: Clin Pharmacokinet Date: 2003 Impact factor: 6.447

2. Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

Authors: Carlo J Milani; Hiroyuki Kobori; John J Mullins; Kenneth D Mitchell
Journal: Am J Med Sci Date: 2010-11 Impact factor: 2.378

3. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.

Authors: Yasunari Takada; Michael Andreeff; Bharat B Aggarwal
Journal: Blood Date: 2005-04-05 Impact factor: 22.113

Review 4. Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation.

Authors: Troy D Hubbard; Iain A Murray; Gary H Perdew
Journal: Drug Metab Dispos Date: 2015-06-03 Impact factor: 3.922

5. Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension.

Authors: Lily Huang; Catherine G Howard; Kenneth D Mitchell
Journal: Am J Med Sci Date: 2012-10 Impact factor: 2.378

Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants.

Review 1. Dietary effects on drug metabolism and transport.

2. Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.

3. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells.

Review 4. Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation.

5. Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent hypertension.

Review 6. Drug metabolism and pharmacokinetics in malutrition.

7. The effect of a diet rich in brussels sprouts on warfarin pharmacokinetics.

8. Paracetamol as a test drug to determine glucuronide formation in man. Effects of inducers and of smoking.

Review 9. Vegetables, fruit, and cancer. II. Mechanisms.

10. Anti-adult T-cell leukemia/lymphoma effects of indole-3-carbinol.