Literature DB >> 1127723

Carcinogenic effects of Di-n-propylnitrosamine, beta-hydroxypropyl-n-propylnitrosamine, and methyl-n-propylnitrosamine on Sprague-Dawlay rats.

G Reznik, U Mohr, F W Krüger.   

Abstract

The carcinogenic effects of di-n-propylnitrosamine and its two related compounds, beta-hydroxypropyl-n-propylnitrosamine (HPPN) and methyl-n-propylnitrosamine (MPN), were tested in rats and compared. All three substances induced neoplasms in the nasal and paranasal cavities, esophagus, and liver. MPN treatment caused the highest tumor incidence in the esophagus, whereas HPPN induced the most hepatic tumors.

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Year:  1975        PMID： 1127723

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  7 in total

1.  The carcinogenic effect of 2,2-dioxopropylnitrosamine on the renal pelvic epithelium of Sprague-Dawley rats, after chronic subcutaneous injections.

Authors:  M Solé; A Cardesa; J Domingo; U Mohr
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  The carcinogenic effect of beta oxydized dipropylnitrosamine in mice. II. 2-hydroxypropyl-n-propylnitrosamine and 2-oxo-propyl-n-propylnitrosamine.

Authors:  S Dickhaus; G Reznik; U Green; M Ketkar
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978-05-31

3.  The carcinogenic effect of beta-oxidized dipropylnitrosamine in mice. I. Dipropylnitrosamine and methyl-propylnitrosamine.

Authors:  S Dickhaus; G Reznik; U Green; M Ketkar
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-12-15

4.  Comparison of the effect of beta-oxidized dipropylnitrosamine metabolites administered at equimolar doses to Syrian hamsters.

Authors:  J Althoff; C Grandjean; P Pour; B Bertram
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-11-18

5.  Carcinogenicity of 1-oxopropylpropylnitrosamine (N-nitroso-N-propyl-proprionamide) in Syrian hamsters.

Authors:  J Althoff; C Grandjean; B Gold; R Runge
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-12-15

6.  Mutagenicity of beta-oxidized N,N,-di-n-propylnitrosamine derivatives in S. typhimurium mediated by rat and hamster tissues.

Authors:  A Camus; B Bertram; F W Krüger; C Malaveille; H Bartsch
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-08-30

7.  Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2-dibromo-3-chloropropane.

Authors:  G Reznik; H Reznik-Schüller; J M Ward; S F Stinson
Journal:  Br J Cancer       Date:  1980-11       Impact factor: 7.640
  7 in total

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