Literature DB >> 11276404

The pathophysiology and treatment of autism.

D J Posey1, C J McDougle.   

Abstract

This article critically reviews research done in the past 2 years concerning the pathophysiology and treatment of autism. Recent research in genetics, neuroimaging, neurochemistry, and pharmacologic treatment has advanced the body of knowledge about the pathophysiology of autism. Relatively new imaging technologies (eg, positron emission tomography) are increasingly being applied to the study of subjects with autism and have produced promising results that await replication. Neurochemical and challenge studies continue to suggest a role for 5-HT dysregulation in autism. Additional research is needed to determine the role of neuroendocrine and autoimmune factors in autism. Significant gains have been made in determining which pharmacologic treatments are efficacious in autism. Additional research is needed on agents that might ameliorate the core and associated symptoms of autism.

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Year:  2001        PMID： 11276404     DOI： 10.1007/s11920-001-0006-1

Source DB:  PubMed          Journal:  Curr Psychiatry Rep        ISSN： 1523-3812            Impact factor:   5.285


  58 in total

1.  Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder.

Authors:  J P Lassig; K Vachirasomtoon; K Hartzell; M Leventhal; E Courchesne; R Courchesne; C Lord; B L Leventhal; E H Cook
Journal:  Am J Med Genet       Date:  1999-10-15

2.  Absence of linkage and linkage disequilibrium to chromosome 15q11-q13 markers in 139 multiplex families with autism.

Authors:  B Salmon; J Hallmayer; T Rogers; L Kalaydjieva; P B Petersen; P Nicholas; C Pingree; W McMahon; D Spiker; L Lotspeich; H Kraemer; P McCague; S Dimiceli; N Nouri; T Pitts; J Yang; D Hinds; R M Myers; N Risch
Journal:  Am J Med Genet       Date:  1999-10-15

3.  An MRI study of the basal ganglia in autism.

Authors:  L L Sears; C Vest; S Mohamed; J Bailey; B J Ranson; J Piven
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  1999-05       Impact factor: 5.067

4.  Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence.

Authors:  E H Cook; B L Leventhal; W Heller; J Metz; M Wainwright; D X Freedman
Journal:  J Neuropsychiatry Clin Neurosci       Date:  1990       Impact factor: 2.198

5.  A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder.

Authors:  W M Bolman; J A Richmond
Journal:  J Autism Dev Disord       Date:  1999-06

6.  Social intelligence in the normal and autistic brain: an fMRI study.

Authors:  S Baron-Cohen; H A Ring; S Wheelwright; E T Bullmore; M J Brammer; A Simmons; S C Williams
Journal:  Eur J Neurosci       Date:  1999-06       Impact factor: 3.386

7.  Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study.

Authors:  A Philippe; M Martinez; M Guilloud-Bataille; C Gillberg; M Råstam; E Sponheim; M Coleman; M Zappella; H Aschauer; L Van Maldergem; C Penet; J Feingold; A Brice; M Leboyer; L van Malldergerme
Journal:  Hum Mol Genet       Date:  1999-05       Impact factor: 6.150

8.  B lymphocyte antigen D8/17 and repetitive behaviors in autism.

Authors:  E Hollander; G DelGiudice-Asch; L Simon; J Schmeidler; C Cartwright; C M DeCaria; J Kwon; C Cunningham-Rundles; F Chapman; J B Zabriskie
Journal:  Am J Psychiatry       Date:  1999-02       Impact factor: 18.112

Review 9.  Autism and Clostridium tetani.

Authors:  E R Bolte
Journal:  Med Hypotheses       Date:  1998-08       Impact factor: 1.538

10.  A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders.

Authors:  C J McDougle; J P Holmes; D C Carlson; G H Pelton; D J Cohen; L H Price
Journal:  Arch Gen Psychiatry       Date:  1998-07
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  1 in total

Review 1.  The neurobiological context of autism.

Authors:  Flavio Keller; Antonio M Persico
Journal:  Mol Neurobiol       Date:  2003-08       Impact factor: 5.590
  1 in total

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