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Literature DB >> 11276397

How long should telomeres be?

Abstract

What began as a study of the "end-replication problem" took on a new dimension as it became clear that telomeres are a "molecular clock" of replication in human somatic cells. Here we review the biology of telomeres in vitro and in vivo, in mice and humans. We suggest that, in humans, telomeres are involved in the biology of aging and pathobiology of disorders of aging, including cancer and cardiovascular disease. We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories.

Entities: Disease Species

Mesh：

Year: 2001 PMID： 11276397 DOI： 10.1007/s11906-001-0029-3

Source DB: PubMed Journal: Curr Hypertens Rep ISSN： 1522-6417 Impact factor: 5.369

92 in total

Review 1. Role of oxidative stress in telomere length regulation and replicative senescence.

Authors: T von Zglinicki
Journal: Ann N Y Acad Sci Date: 2000-06 Impact factor: 5.691

2. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis.

Authors: L Chin; S E Artandi; Q Shen; A Tam; S L Lee; G J Gottlieb; C W Greider; R A DePinho
Journal: Cell Date: 1999-05-14 Impact factor: 41.582

3. Telomerase activity in human germline and embryonic tissues and cells.

Authors: W E Wright; M A Piatyszek; W E Rainey; W Byrd; J W Shay
Journal: Dev Genet Date: 1996

4. Origin of concatemeric T7 DNA.

Authors: J D Watson
Journal: Nat New Biol Date: 1972-10-18

5. Mechanism of telomerase induction during T cell activation.

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Journal: Exp Cell Res Date: 1996-10-10 Impact factor: 3.905

6. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.

Authors: E González-Suárez; E Samper; J M Flores; M A Blasco
Journal: Nat Genet Date: 2000-09 Impact factor: 38.330

7. Extensive telomere repeat arrays in mouse are hypervariable.

Authors: J A Starling; J Maule; N D Hastie; R C Allshire
Journal: Nucleic Acids Res Date: 1990-12-11 Impact factor: 16.971

Review 8. Redox signals that regulate the vascular response to injury.

Authors: B C Berk
Journal: Thromb Haemost Date: 1999-08 Impact factor: 5.249

9. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis.

Authors: R B Effros; R Allsopp; C P Chiu; M A Hausner; K Hirji; L Wang; C B Harley; B Villeponteau; M D West; J V Giorgi
Journal: AIDS Date: 1996-07 Impact factor: 4.177

Review 10. Radical AGEing in Alzheimer's disease.

Authors: M A Smith; L M Sayre; V M Monnier; G Perry
Journal: Trends Neurosci Date: 1995-04 Impact factor: 13.837

7 in total

Review 1. Development, characterization, conservation and storage of fish cell lines: a review.

Authors: W S Lakra; T Raja Swaminathan; K P Joy
Journal: Fish Physiol Biochem Date: 2010-07-06 Impact factor: 2.794

2. Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction.

Authors: Daniel L Smith; Julie A Mattison; Renee A Desmond; Jeffrey P Gardner; Masayuki Kimura; George S Roth; Donald K Ingram; David B Allison; Abraham Aviv
Journal: J Gerontol A Biol Sci Med Sci Date: 2011-08-22 Impact factor: 6.053

3. Events in the immortalizing process of primary human mammary epithelial cells by the catalytic subunit of human telomerase.

Authors: Hyunggee Kim; James Farris; Shelly A Christman; Byung-Whi Kong; Linda K Foster; Scott M O'Grady; Douglas N Foster
Journal: Biochem J Date: 2002-08-01 Impact factor: 3.857