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Literature DB >> 11276229

Morphological correlates of functionally defined synaptic vesicle populations.

Abstract

By combining photoconversion of FM1-43-stained vesicles and electron microscopy of hippocampal synapses, we find evidence that the population of morphologically docked synaptic vesicles corresponds to the release-ready neurotransmitter quanta. Furthermore, those synaptic vesicles that are participating in cycles of exo- and endocytosis tend to be closer to the active zone than vesicles that are being held in reserve.

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Year: 2001 PMID： 11276229 DOI： 10.1038/86042

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

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Cited

187 in total

1. Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion.

Authors: N Harata; T A Ryan; S J Smith; J Buchanan; R W Tsien
Journal: Proc Natl Acad Sci U S A Date: 2001-10-23 Impact factor: 11.205

Review 2. The role of neurotrophins in neurotransmitter release.

Authors: William J Tyler; Stephen P Perrett; Lucas D Pozzo-Miller
Journal: Neuroscientist Date: 2002-12 Impact factor: 7.519

Review 3. Presynaptic frequency- and pattern-dependent filtering.

Authors: Alex M Thomson
Journal: J Comput Neurosci Date: 2003 Sep-Oct Impact factor: 1.621

4. Vesicle pool partitioning influences presynaptic diversity and weighting in rat hippocampal synapses.

Authors: Jack Waters; Stephen J Smith
Journal: J Physiol Date: 2002-06-15 Impact factor: 5.182

5. Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held.

Authors: Christoph J Meinrenken; J Gerard G Borst; Bert Sakmann
Journal: J Physiol Date: 2003-01-31 Impact factor: 5.182

6. Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.

Authors: Brian W Edmonds; Frederick D Gregory; Felix E Schweizer
Journal: J Physiol Date: 2004-08-12 Impact factor: 5.182

Morphological correlates of functionally defined synaptic vesicle populations.

1. Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion.

Review 2. The role of neurotrophins in neurotransmitter release.

Review 3. Presynaptic frequency- and pattern-dependent filtering.

4. Vesicle pool partitioning influences presynaptic diversity and weighting in rat hippocampal synapses.

5. Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held.

6. Evidence that fast exocytosis can be predominantly mediated by vesicles not docked at active zones in frog saccular hair cells.

7. A morphological correlate of synaptic scaling in visual cortex.

8. Determinants of synaptic strength vary across an axon arbor.

Review 9. Ultrastructure of synapses in the mammalian brain.

10. In the zone: presynaptic function at high res.