Literature DB >> 11276224

Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.

A M Salmon1, M I Damaj, L M Marubio, M P Epping-Jordan, E Merlo-Pich, J P Changeux.   

Abstract

The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear. Here we show that mice lacking alpha CGRP display an attenuated response to chemical pain and inflammation. Furthermore, alpha CGRP(-/-) mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of alpha CGRP to opiate withdrawal.

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Year:  2001        PMID： 11276224     DOI： 10.1038/86001

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  42 in total

1.  A nociceptive signaling role for neuromedin B.

Authors:  Santosh K Mishra; Sarah Holzman; Mark A Hoon
Journal:  J Neurosci       Date:  2012-06-20       Impact factor: 6.167

2.  Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene.

Authors:  Jeffrey S Mogil; Frank Miermeister; Frank Seifert; Kate Strasburg; Katharina Zimmermann; Heiko Reinold; Jean-Sebastien Austin; Nadia Bernardini; Elissa J Chesler; Heiko A Hofmann; Christian Hordo; Karl Messlinger; Kumar V S Nemmani; Andrew L Rankin; Jennifer Ritchie; Angela Siegling; Shad B Smith; Susana Sotocinal; Axel Vater; Sonya G Lehto; Sven Klussmann; Remi Quirion; Martin Michaelis; Marshall Devor; Peter W Reeh
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-23       Impact factor: 11.205

3.  Direct interactions between calcitonin-like receptor (CLR) and CGRP-receptor component protein (RCP) regulate CGRP receptor signaling.

Authors:  Sophie C Egea; Ian M Dickerson
Journal:  Endocrinology       Date:  2012-02-07       Impact factor: 4.736

Review 4.  Inhibition of calcitonin gene-related peptide function: a promising strategy for treating migraine.

Authors:  Paul L Durham
Journal:  Headache       Date:  2008-09       Impact factor: 5.887

Review 5.  The mechanism of μ-opioid receptor (MOR)-TRPV1 crosstalk in TRPV1 activation involves morphine anti-nociception, tolerance and dependence.

Authors:  Yanju Bao; Yebo Gao; Liping Yang; Xiangying Kong; Jing Yu; Wei Hou; Baojin Hua
Journal:  Channels (Austin)       Date:  2015-07-15       Impact factor: 2.581

Review 6.  CGRP as a neuropeptide in migraine: lessons from mice.

Authors:  Andrew F Russo
Journal:  Br J Clin Pharmacol       Date:  2015-07-14       Impact factor: 4.335

7.  Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.

Authors:  Paul L Durham; Carrie V Vause
Journal:  CNS Drugs       Date:  2010-07       Impact factor: 5.749

8.  Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal.

Authors:  Tuan Trang; Maaja Sutak; Remi Quirion; Khem Jhamandas
Journal:  Br J Pharmacol       Date:  2003-08-26       Impact factor: 8.739

9.  Extreme tolerance to ammonia fumes in African naked mole-rats: animals that naturally lack neuropeptides from trigeminal chemosensory nerve fibers.

Authors:  Pamela Colleen LaVinka; Antje Brand; Victoria J Landau; David Wirtshafter; Thomas J Park
Journal:  J Comp Physiol A Neuroethol Sens Neural Behav Physiol       Date:  2009-02-15       Impact factor: 1.836

10.  Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain.

Authors:  Masako Nakanishi; Kenji Hata; Tomotaka Nagayama; Teruhisa Sakurai; Toshihiko Nishisho; Hiroki Wakabayashi; Toru Hiraga; Shigeyuki Ebisu; Toshiyuki Yoneda
Journal:  Mol Biol Cell       Date:  2010-06-09       Impact factor: 4.138
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