| Literature DB >> 112754 |
B Haider, C K Yeh, G Thomas, H A Oldewurtel, M M Lyons, T J Regan.
Abstract
We have demonstrated that in rhesus monkeys, 18 months of diabetes alters the end-diastolic pressure, end-diastolic volume relations without hypertrophy. Accumulation of collagen in the myocardial interstitium was the apparent basis for abnormal left ventricular performance. Neither collagen concentration nor left ventricular performance were signigicantly affected by dietary lipid composition. These myocardial abnormalities occurred at a stage when coronary atherosclerosis was limited. However, the relative influence of coronary atherosclerosis and myocardial alterations during more prolonged lipid feeding remains to be determined.Entities:
Mesh:
Substances:
Year: 1978 PMID: 112754
Source DB: PubMed Journal: Trans Assoc Am Physicians ISSN: 0066-9458