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Literature DB >> 11274440

Differences in quantal amplitude reflect GluR4- subunit number at corticothalamic synapses on two populations of thalamic neurons.

Abstract

Low-frequency thalamocortical oscillations that underlie drowsiness and slow-wave sleep depend on rhythmic inhibition of relay cells by neurons in the reticular nucleus (RTN) under the influence of corticothalamic fibers that branch to innervate RTN neurons and relay neurons. To generate oscillations, input to RTN predictably should be stronger so disynaptic inhibition of relay cells overcomes direct corticothalamic excitation. Amplitudes of excitatory postsynaptic conductances (EPSCs) evoked in RTN neurons by minimal stimulation of corticothalamic fibers were 2.4 times larger than in relay neurons, and quantal size of RTN EPSCs was 2.6 times greater. GluR4-receptor subunits labeled at corticothalamic synapses on RTN neurons outnumbered those on relay cells by 3.7 times, providing a basis for differences in synaptic strength.

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Year: 2001 PMID： 11274440 PMCID： PMC31198 DOI： 10.1073/pnas.061013698

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

47 in total

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Authors: P Golshani; R A Warren; E G Jones
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Differences in quantal amplitude reflect GluR4- subunit number at corticothalamic synapses on two populations of thalamic neurons.

1. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus.

2. Distribution of AMPA selective glutamate receptors in the thalamus of adult rats and during postnatal development. A light and ultrastructural immunocytochemical study.

3. Oscillatory synaptic interactions between ventroposterior and reticular neurons in mouse thalamus in vitro.

4. Single axon excitatory postsynaptic potentials in neocortical interneurons exhibit pronounced paired pulse facilitation.

5. Physiology and pharmacology of corticothalamic stimulation-evoked responses in rat somatosensory thalamic neurons in vitro.

6. Maturation of neuronal form and function in a mouse thalamo-cortical circuit.

7. Corticothalamic projections from the cortical barrel field to the somatosensory thalamus in rats: a single-fibre study using biocytin as an anterograde tracer.

8. Residual Ca2+ and short-term synaptic plasticity.

9. Progression of change in NMDA, non-NMDA, and metabotropic glutamate receptor function at the developing corticothalamic synapse.

10. Post-tetanic potentiation and facilitation of synaptic potentials evoked in cat spinal motoneurones.

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