Literature DB >> 11274433

Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle.

S Song1, P J Laipis, K I Berns, T R Flotte.   

Abstract

We report here that the DNA-dependent protein kinase (DNA-PK) affects the molecular fate of the recombinant adeno-associated virus (rAAV) genome in skeletal muscle. rAAV-human alpha1-antitrypsin (rAAV-hAAT) vectors were delivered by intramuscular injection to either C57BL/6 (DNA-PKcs(+)) or C57BL/6-SCID [severe combined immunodeficient (SCID), DNA-PKcs(-)] mice. In both strains, high levels of transgene expression were sustained for up to 1 year after a single injection. Southern blot analysis showed that rAAV genomes persisted as linear episomes for more than 1 year in SCID mice, whereas only circular episomal forms were observed in the C57BL/6 strain. These results indicate that DNA-PK is involved in the formation of circular rAAV episomes.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11274433      PMCID： PMC31183          DOI： 10.1073/pnas.061014598

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Loss of ATM function enhances recombinant adeno-associated virus transduction and integration through pathways similar to UV irradiation.

Authors:  S Sanlioglu; P Benson; J F Engelhardt
Journal:  Virology       Date:  2000-03-01       Impact factor: 3.616

2.  Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes.

Authors:  J S Danska; D P Holland; S Mariathasan; K M Williams; C J Guidos
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

3.  Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector.

Authors:  X Xiao; J Li; R J Samulski
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

4.  Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors.

Authors:  H Nakai; T A Storm; M A Kay
Journal:  Nat Biotechnol       Date:  2000-05       Impact factor: 54.908

5.  Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.

Authors:  L Chen; K Trujillo; P Sung; A E Tomkinson
Journal:  J Biol Chem       Date:  2000-08-25       Impact factor: 5.157

6.  Adenovirus E4 34k and E4 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase.

Authors:  J Boyer; K Rohleder; G Ketner
Journal:  Virology       Date:  1999-10-25       Impact factor: 3.616

7.  Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver.

Authors:  H Nakai; Y Iwaki; M A Kay; L B Couto
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

8.  Gene delivery to skeletal muscle results in sustained expression and systemic delivery of a therapeutic protein.

Authors:  P D Kessler; G M Podsakoff; X Chen; S A McQuiston; P C Colosi; L A Matelis; G J Kurtzman; B J Byrne
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

9.  Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

Authors:  T Blunt; D Gell; M Fox; G E Taccioli; A R Lehmann; S P Jackson; P A Jeggo
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

Review 10.  Adeno-associated virus vectors for gene therapy.

Authors:  T R Flotte; B J Carter
Journal:  Gene Ther       Date:  1995-08       Impact factor: 5.250
View more
  42 in total

1.  Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome.

Authors:  L Zentilin; A Marcello; M Giacca
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

2.  Genetic fate of recombinant adeno-associated virus vector genomes in muscle.

Authors:  Bruce C Schnepp; K Reed Clark; Dori L Klemanski; Christina A Pacak; Philip R Johnson
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

3.  Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway.

Authors:  Shu-Husan Chou; Jen-Hsin Kao; Pao-Luh Tao; Ping-Yee Law; Horace H Loh
Journal:  Synapse       Date:  2012-03-31       Impact factor: 2.562

4.  Differential effects of DNA double-strand break repair pathways on single-strand and self-complementary adeno-associated virus vector genomes.

Authors:  Marcela P Cataldi; Douglas M McCarty
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

Review 5.  Adeno-associated Virus as a Mammalian DNA Vector.

Authors:  Max Salganik; Matthew L Hirsch; Richard Jude Samulski
Journal:  Microbiol Spectr       Date:  2015-08

6.  Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.

Authors:  Mong-Jen Chen; Yuanqing Lu; Takashi Hamazaki; Hsin-Yin Tsai; Kirsten Erger; Thomas Conlon; Ahmed S Elshikha; Hong Li; Arun Srivastava; Chunli Yao; Mark Brantly; Vince Chiodo; William Hauswirth; Naohiro Terada; Sihong Song
Journal:  Hum Gene Ther Methods       Date:  2013-12-28       Impact factor: 2.396

7.  AAV5-mediated gene transfer to the parotid glands of non-human primates.

Authors:  A Voutetakis; C Zheng; A P Cotrim; F Mineshiba; S Afione; N Roescher; W D Swaim; M Metzger; M A Eckhaus; R E Donahue; C E Dunbar; J A Chiorini; B J Baum
Journal:  Gene Ther       Date:  2009-09-17       Impact factor: 5.250

8.  Systemic delivery of IL-27 by an adeno-associated viral vector inhibits T cell-mediated colitis and induces multiple inhibitory pathways in T cells.

Authors:  Xiaotong Zhu; Zhihao Liu; Jin-Qing Liu; Jianmin Zhu; Jianchao Zhang; Jonathan P Davis; Jianhong Chu; Jianhua Yu; Jie Zhou; Ming-Song Li; Xue-Feng Bai
Journal:  J Leukoc Biol       Date:  2016-04-22       Impact factor: 4.962

9.  Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle.

Authors:  Bruce C Schnepp; Jeffrey D Chulay; Guo-Jie Ye; Terence R Flotte; Bruce C Trapnell; Philip R Johnson
Journal:  Hum Gene Ther       Date:  2016-01       Impact factor: 5.695

10.  Immunotherapy: rAAV2 expressing interleukin-15 inhibits HeLa cell tumor growth in mice.

Authors:  Giou-Teng Yiang; Horng-Jyh Harn; Yung-Luen Yu; Sheng-Chuan Hu; Yu-Ting Hung; Chia-Jung Hsieh; Shinn-Zong Lin; Chyou-Wei Wei
Journal:  J Biomed Sci       Date:  2009-05-07       Impact factor: 8.410
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.