Literature DB >> 11272288

Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects.

Z Lakovidou1, A Papageorgiou, M A Demertzis, E Mioglou, D Mourelatos, A Kotsis, P N Yadav, D Kovala-Demertzi.   

Abstract

The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)2] x H2O and [Pd(AcTsc)2] while the rest, i.e. (HAcTsc), [Pt(AcTsc)Cl], [Pt(HAcTsc)2]Cl2 x 2H2O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)2]Cl2, displayed marginal cytogenetic and antitumor effects.

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Year:  2001        PMID： 11272288     DOI： 10.1097/00001813-200101000-00009

Source DB:  PubMed          Journal:  Anticancer Drugs        ISSN： 0959-4973            Impact factor:   2.248


  6 in total

1.  Novel 1-indanone Thiosemicarbazone Antiviral Candidates: Aqueous Solubilization and Physical Stabilization by Means of Cyclodextrins.

Authors:  Romina J Glisoni; Diego A Chiappetta; Albertina G Moglioni; Alejandro Sosnik
Journal:  Pharm Res       Date:  2011-10-06       Impact factor: 4.200

2.  Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity.

Authors:  Joanna Wiecek; Dimitra Kovala-Demertzi; Zbigniew Ciunik; Joanna Wietrzyk; Maria Zervou; Mavroudis A Demertzis
Journal:  Bioinorg Chem Appl       Date:  2010-05-12       Impact factor: 7.778

3.  Synthesis, characterization, and antibacterial and anticancer screening of {M(2+)-Co (3+)-M (2+)} and {Co (3+)-M (2+)} (M is Zn, Cd, Hg) heterometallic complexes.

Authors:  Nagendra K Kaushik; Anurag Mishra; Afsar Ali; J S Adhikari; Akhilesh K Verma; Rajeev Gupta
Journal:  J Biol Inorg Chem       Date:  2012-09-23       Impact factor: 3.358

4.  Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole.

Authors:  Karolina Stryjska; Lidia Radko; Lilianna Chęcińska; Joachim Kusz; Andrzej Posyniak; Justyn Ochocki
Journal:  Int J Mol Sci       Date:  2020-05-21       Impact factor: 5.923

5.  Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities.

Authors:  Ayşegül Karaküçük-İyidoğan; Demet Taşdemir; Emine Elçin Oruç-Emre; Jan Balzarini
Journal:  Eur J Med Chem       Date:  2011-10-01       Impact factor: 6.514

6.  Bis-pharmacophore of cinnamaldehyde-clubbed thiosemicarbazones as potent carbonic anhydrase-II inhibitors.

Authors:  Asif Rasool; Zahra Batool; Majid Khan; Sobia Ahsan Halim; Zahid Shafiq; Ahmed Temirak; Mohamed A Salem; Tarik E Ali; Ajmal Khan; Ahmed Al-Harrasi
Journal:  Sci Rep       Date:  2022-09-27       Impact factor: 4.996
  6 in total

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