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Literature DB >> 11270727

Monoamine oxidase inhibitors from rhizoma of Coptis chinensis.

Abstract

Three protoberberine alkaloids jatrorrhizine, berberine and palmatine were isolated from the monoamine oxidase (MAO) inhibitory fraction of the methanol extract of Coptis chinensis rhizoma. Jatrorrhizine was shown to inhibit non-competitively both MAO-A and -B from rat brain mitochondria with the IC50 values of 4 and 62 microM, respectively. Berberine only competitively inhibited MAO-A with an IC50 values of 126 microM whereas palmatine exhibited, up to 200 microM, no inhibition on any type of the enzyme. The structure-activity relationship was briefly discussed.

Entities: Chemical Gene Species

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Year: 2001 PMID： 11270727 DOI： 10.1055/s-2001-10874

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

19 in total

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Review 3. Selective MAO-B inhibitors: a lesson from natural products.

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Journal: Mol Divers Date: 2013-11-12 Impact factor: 2.943

Review 4. Traditional chinese medicine in treatment of metabolic syndrome.

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5. Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy.

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Journal: J Med Food Date: 2013-06-04 Impact factor: 2.786

Review 6. Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases.

Authors: Esra Küpeli Akkol; Irem Tatlı Çankaya; Gökçe Şeker Karatoprak; Elif Carpar; Eduardo Sobarzo-Sánchez; Raffaele Capasso
Journal: Front Pharmacol Date: 2021-05-13 Impact factor: 5.810

Monoamine oxidase inhibitors from rhizoma of Coptis chinensis.

1. Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine.

Review 2. Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends.

Review 3. Selective MAO-B inhibitors: a lesson from natural products.

Review 4. Traditional chinese medicine in treatment of metabolic syndrome.

5. Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy.

Review 6. Natural Compounds as Medical Strategies in the Prevention and Treatment of Psychiatric Disorders Seen in Neurological Diseases.

7. Molecular basis of inhibitory activities of berberine against pathogenic enzymes in Alzheimer's disease.

Review 8. Potential benefits of berberine in the management of perimenopausal syndrome.

9. Therapeutic effect of berberine on TDP-43-related pathogenesis in FTLD and ALS.

10. A Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors.