OBJECTIVE: To determine whether uric acid in plasma of patients registered at a PCC varies with the season. DESIGN: Descriptive study, with two transversal cuts, one in winter and one in summer. SETTING: Health district on the outskirts of Valencia. PATIENTS: Selected at random from all patients over 18 with medical records, with appointments in January-February and July-August 1999. Sample size was calculated for paired data with an alpha error of 0.05 and beta error of 20%. The pertinent level of uraemia was set at 0.4 mg/dl. Variability was deduced from a mini-sample of 17 cases in a sample of 72 patients. The following were recorded: sex, age, BMI, blood count, glucaemia, total cholesterol, HDL-c, LDL-c, uric acid and triglycerides. Meteorological data were supplied by the Valencia Weather Centre. MEASUREMENTS AND MAIN RESULTS: Temperature (12.8 degrees C versus 25.8 degrees C), sun (9.9 hours a day versus 5.9) and relative humidity (67.1% versus 61.4%) were greater in summer than in winter. There were no differences in mean atmospheric pressure (760.1 mmHg versus 760.7). 75 patients with a mean age of 63 finished the study. Mean uric acid was higher in summer at 5.64 mg/dl (95% CI, 5.29-5.99) than in winter at 5.23 mg/dl (CI, 4.92-5.56). We found no significant differences in the BMI, red corpuscles, haematocrits, glucaemia, total or divided cholesterol, or triglycerides. CONCLUSION: Seasonal variation in the plasma concentration of uric acid was found in the sample studied.
OBJECTIVE: To determine whether uric acid in plasma of patients registered at a PCC varies with the season. DESIGN: Descriptive study, with two transversal cuts, one in winter and one in summer. SETTING: Health district on the outskirts of Valencia. PATIENTS: Selected at random from all patients over 18 with medical records, with appointments in January-February and July-August 1999. Sample size was calculated for paired data with an alpha error of 0.05 and beta error of 20%. The pertinent level of uraemia was set at 0.4 mg/dl. Variability was deduced from a mini-sample of 17 cases in a sample of 72 patients. The following were recorded: sex, age, BMI, blood count, glucaemia, total cholesterol, HDL-c, LDL-c, uric acid and triglycerides. Meteorological data were supplied by the Valencia Weather Centre. MEASUREMENTS AND MAIN RESULTS: Temperature (12.8 degrees C versus 25.8 degrees C), sun (9.9 hours a day versus 5.9) and relative humidity (67.1% versus 61.4%) were greater in summer than in winter. There were no differences in mean atmospheric pressure (760.1 mmHg versus 760.7). 75 patients with a mean age of 63 finished the study. Mean uric acid was higher in summer at 5.64 mg/dl (95% CI, 5.29-5.99) than in winter at 5.23 mg/dl (CI, 4.92-5.56). We found no significant differences in the BMI, red corpuscles, haematocrits, glucaemia, total or divided cholesterol, or triglycerides. CONCLUSION: Seasonal variation in the plasma concentration of uric acid was found in the sample studied.
Authors: Mary K Townsend; Ying Bao; Clary B Clish; Shelley S Tworoger; Elizabeth M Poole; Kimberly A Bertrand; Peter Kraft; Brian M Wolpin Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-03-03 Impact factor: 4.254
Authors: Heon-Jeong Lee; Hyun Goo Woo; Tiffany A Greenwood; Daniel F Kripke; John R Kelsoe Journal: J Affect Disord Date: 2012-08-25 Impact factor: 6.533