| Literature DB >> 112679 |
T J Brozoski, R M Brown, H E Rosvold, P S Goldman.
Abstract
Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.Entities:
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Year: 1979 PMID： 112679 DOI： 10.1126/science.112679
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728