Literature DB >> 11267623

Anticonvulsant properties of N-salicyloyltryptamine in mice.

F A Oliveira1, R N de Almeida, M F Sousa, J M Barbosa-Filho, S A Diniz, I A de Medeiros.   

Abstract

A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of animals that exhibited PTZ-induced seizures and eliminated the extensor reflex of maximal electric-induced seizures test in 50% of the experimental animals. In addition, it showed protection in the PTZ test by diminishing the death rate.

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Year:  2001        PMID： 11267623     DOI： 10.1016/s0091-3057(00)00484-6

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  9 in total

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2.  Anticonvulsant Activity of trans-Anethole in Mice.

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3.  Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents.

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4.  Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach.

Authors:  Lucindo J Quintans; Davi A Silva; Jullyana S Siqueira; Adriano A S Araújo; Rosana S S Barreto; Leonardo R Bonjardim; Josimari M Desantana; Waldeci De Lucca; Maria F V Souza; Stanley J C Gutierrez; José Maria Barbosa-Filho; Valter J Santana-Filho; Demétrius A M Araújo; Reinaldo N Almeida
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5.  N-salicyloyltryptamine, a new anticonvulsant drug, acts on voltage-dependent Na+, Ca2+, and K+ ion channels.

Authors:  Démetrius Antonio Machado Araújo; Roberta Amaral Mafra; Andréia Laura Prates Rodrigues; Válter Miguel-Silva; Paulo Sérgio Lacerda Beirão; Reinaldo Nóbrega de Almeida; Lucindo Quintans; Maria Fátima Vanderlei de Souza; Jader Santos Cruz
Journal:  Br J Pharmacol       Date:  2003-12       Impact factor: 8.739

6.  Central Nervous System Effects of Iso-6-spectaline Isolated from Senna Spectabilis var. Excelsa (Schrad) in Mice.

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Authors:  Lidianne Mayra Lopes Campêlo; Antonia Amanda C de Almeida; Rizângela L Mendes de Freitas; Gilberto Santos Cerqueira; Geane Felix de Sousa; Gláucio Barros Saldanha; Chistiane Mendes Feitosa; Rivelilson Mendes de Freitas
Journal:  J Biomed Biotechnol       Date:  2011-05-31

8.  Modulation of c-Fos and BDNF protein expression in pentylenetetrazole-kindled mice following the treatment with novel antiepileptic compound HHL-6.

Authors:  Saima Mahmood Malhi; Huma Jawed; Farina Hanif; Nadeem Ashraf; Farhat Zubair; Bina S Siddiqui; Sabira Begum; Nurul Kabir; Shabana Usman Simjee
Journal:  Biomed Res Int       Date:  2014-01-29       Impact factor: 3.411

9.  N-Salicyloyltryptamine, an N-Benzoyltryptamine Analogue, Induces Vasorelaxation through Activation of the NO/sGC Pathway and Reduction of Calcium Influx.

Authors:  Robson Cavalcante Veras; Darizy Flávia Silva; Lorena Soares Bezerra; Valéria Lopes de Assis; Walma Pereira de Vasconcelos; Maria do Carmo Alustau; José George Ferreira de Albuquerque; Fabíola Fialho Furtado; Islania Giselia de Albuquerque Araújo; Fátima de Lourdes Assunção Araújo de Azevedo; Thais Porto Ribeiro; José Maria Barbosa-Filho; Stanley Juan Chavez Gutierrez; Isac Almeida Medeiros
Journal:  Molecules       Date:  2018-01-28       Impact factor: 4.411
  9 in total

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