Literature DB >> 11266422

SHV-27, a novel cefotaxime-hydrolysing beta-lactamase, identified in Klebsiella pneumoniae isolates from a Brazilian hospital.

J E Corkill1, L E Cuevas, R Q Gurgel, J Greensill, C A Hart.   

Abstract

From a collection of cefotaxime-resistant Klebsiella pneumoniae isolated from neonatal blood culture specimens in a maternity hospital in Aracaju, Brazil, two isolates (strains KPBRZ-842 and -843, indistinguishable by pulsed-field gel electrophoresis) were found to produce beta-lactamases with isoelectric points (pI) of 5.4 and 8.2, respectively. Using a gel overlay method, cefotaxime hydrolysis was shown to be associated with the pI 8.2 protein. Nucleotide sequencing of the gene encoding the pI 8.2 beta-lactamase revealed a bla(SHV-ESBL)-type gene differing from the gene encoding SHV-1 by three silent point mutations, and a fourth that resulted in an amino acid substitution, aspartate for glycine, at position 156. This novel SHV-type extended-spectrum beta-lactamase is designated SHV-27.

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Year:  2001        PMID： 11266422     DOI： 10.1093/jac/47.4.463

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  8 in total

1.  SHV-1 beta-lactamase is mainly a chromosomally encoded species-specific enzyme in Klebsiella pneumoniae.

Authors:  J Chaves; M G Ladona; C Segura; A Coira; R Reig; C Ampurdanés
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

2.  Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding.

Authors:  R Christopher D Furniss; Nikol Kaderabkova; Declan Barker; Patricia Bernal; Evgenia Maslova; Amanda A A Antwi; Helen E McNeil; Hannah L Pugh; Laurent Dortet; Jessica M A Blair; Gerald Larrouy-Maumus; Ronan R McCarthy; Diego Gonzalez; Despoina A I Mavridou
Journal:  Elife       Date:  2022-01-13       Impact factor: 8.713

3.  Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaTEM-155.

Authors:  C Hal Jones; Alexey Ruzin; Margareta Tuckman; Melissa A Visalli; Peter J Petersen; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

4.  Multidrug-resistant Klebsiella pneumoniae harboring extended spectrum β-lactamase encoding genes isolated from human septicemias.

Authors:  Isabel Carvalho; Nadia Safia Chenouf; José António Carvalho; Ana Paula Castro; Vanessa Silva; Rosa Capita; Carlos Alonso-Calleja; Maria de Lurdes Nunes Enes Dapkevicius; Gilberto Igrejas; Carmen Torres; Patrícia Poeta
Journal:  PLoS One       Date:  2021-05-04       Impact factor: 3.240

5.  Nosocomial bloodstream infections caused by Klebsiella pneumoniae: impact of extended-spectrum beta-lactamase (ESBL) production on clinical outcome in a hospital with high ESBL prevalence.

Authors:  Alexandre R Marra; Sérgio B Wey; Adauto Castelo; Ana Cristina Gales; Ruy Guilherme R Cal; José R do Carmo Filho; Michael B Edmond; Carlos Alberto P Pereira
Journal:  BMC Infect Dis       Date:  2006-02-14       Impact factor: 3.090

Review 6.  A Review of SHV Extended-Spectrum β-Lactamases: Neglected Yet Ubiquitous.

Authors:  Apostolos Liakopoulos; Dik Mevius; Daniela Ceccarelli
Journal:  Front Microbiol       Date:  2016-09-05       Impact factor: 5.640

Review 7.  Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins.

Authors:  Jorge Luiz Mello Sampaio; Ana Cristina Gales
Journal:  Braz J Microbiol       Date:  2016-10-25       Impact factor: 2.476

8.  Global Trends in Proteome Remodeling of the Outer Membrane Modulate Antimicrobial Permeability in Klebsiella pneumoniae.

Authors:  Andrea Rocker; Jake A Lacey; Matthew J Belousoff; Jonathan J Wilksch; Richard A Strugnell; Mark R Davies; Trevor Lithgow
Journal:  mBio       Date:  2020-04-14       Impact factor: 7.867
  8 in total

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