| Literature DB >> 11266181 |
J G Darker1, R A Porter, D S Eggleston, D Smart, S J Brough, C Sabido-David, J C Jerman.
Abstract
Truncated peptide analogues of orexin-A were prepared and their biological activity assesed at the orexin-1 receptor. Progressive N-terminal deletions identified the minimum C-terminal sequence required for maintaining a significant agonist effect, whilst an alanine scan and other pertinent substitutions identified key side-chain and stereochemical requirements for receptor activation.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11266181 DOI： 10.1016/s0960-894x(01)00043-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823