Literature DB >> 11266176

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

R L Jarvest1, J M Berge, P Brown, D W Hamprecht, D J McNair, L Mensah, P J O'Hanlon, A J Pope.   

Abstract

Novel pyranosyl analogues of SB-219383 have been synthesised to elucidate the structure-activity relationships around the pyran ring. Analogues with highly potent stereoselective and bacterioselective inhibition of bacterial tyrosyl tRNA synthetase have been identified. A major reduction in the overall polarity of the molecule can be tolerated without loss of the nanomolar level of inhibition.

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Year:  2001        PMID： 11266176     DOI： 10.1016/s0960-894x(01)00040-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.

Authors:  X Qiu; C A Janson; W W Smith; S M Green; P McDevitt; K Johanson; P Carter; M Hibbs; C Lewis; A Chalker; A Fosberry; J Lalonde; J Berge; P Brown; C S Houge-Frydrych; R L Jarvest
Journal:  Protein Sci       Date:  2001-10       Impact factor: 6.725

2.  Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons.

Authors:  Medha Raina; Adil Moghal; Amanda Kano; Mathew Jerums; Paul D Schnier; Shun Luo; Rohini Deshpande; Pavel V Bondarenko; Henry Lin; Michael Ibba
Journal:  J Biol Chem       Date:  2014-05-14       Impact factor: 5.157

3.  Statistical evaluation of the Rodin-Ohno hypothesis: sense/antisense coding of ancestral class I and II aminoacyl-tRNA synthetases.

Authors:  Srinivas Niranj Chandrasekaran; Galip Gürkan Yardimci; Ozgün Erdogan; Jeffrey Roach; Charles W Carter
Journal:  Mol Biol Evol       Date:  2013-04-10       Impact factor: 16.240
  3 in total

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