Literature DB >> 11266159

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

D G Smith1, M Buffet, A E Fenwick, D Haigh, R J Ife, M Saunders, B P Slingsby, R Stacey, R W Ward.   

Abstract

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases.

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Year:  2001        PMID： 11266159     DOI： 10.1016/s0960-894x(00)00721-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  28 in total

Review 1.  GSK-3: tricks of the trade for a multi-tasking kinase.

Authors:  Bradley W Doble; James R Woodgett
Journal:  J Cell Sci       Date:  2003-04-01       Impact factor: 5.285

2.  Convenient synthesis of N1-substituted orotic acid derivatives.

Authors:  Jeannette T Bowler; Caitlin R Clausen; Daniel J Blackburn; Weiming Wu
Journal:  Tetrahedron Lett       Date:  2014-11-19       Impact factor: 2.415

3.  Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.

Authors:  Karina Förster; Heike Richter; Mikhail F Alexeyev; Dieter Rosskopf; Stephan B Felix; Thomas Krieg
Journal:  Clin Exp Pharmacol Physiol       Date:  2010-03-12       Impact factor: 2.557

4.  New leads for selective GSK-3 inhibition: pharmacophore mapping and virtual screening studies.

Authors:  Dhilon S Patel; Prasad V Bharatam
Journal:  J Comput Aided Mol Des       Date:  2006-04-19       Impact factor: 3.686

5.  Pharmacophore-based screening and drug repurposing exemplified on glycogen synthase kinase-3 inhibitors.

Authors:  Luminita Crisan; Sorin Avram; Liliana Pacureanu
Journal:  Mol Divers       Date:  2017-01-21       Impact factor: 2.943

Review 6.  In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases.

Authors:  C I Wells; N R Kapadia; R M Couñago; D H Drewry
Journal:  Medchemcomm       Date:  2017-12-08       Impact factor: 3.597

7.  A retinoic acid-dependent network in the foregut controls formation of the mouse lung primordium.

Authors:  Felicia Chen; Yuxia Cao; Jun Qian; Fengzhi Shao; Karen Niederreither; Wellington V Cardoso
Journal:  J Clin Invest       Date:  2010-05-17       Impact factor: 14.808

Review 8.  Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal.

Authors:  Chandra Sekhar Kuruva; P Hemachandra Reddy
Journal:  Drug Discov Today       Date:  2016-10-27       Impact factor: 7.851

9.  Lack of Muc1-regulated beta-catenin stability results in aberrant expansion of CD11b+Gr1+ myeloid-derived suppressor cells from the bone marrow.

Authors:  Tze Wei Poh; Judy M Bradley; Pinku Mukherjee; Sandra J Gendler
Journal:  Cancer Res       Date:  2009-04-07       Impact factor: 12.701

10.  The marine natural-derived inhibitors of glycogen synthase kinase-3beta phenylmethylene hydantoins: In vitro and in vivo activities and pharmacophore modeling.

Authors:  Mohammad A Khanfar; Bilal Abu Asal; Mudit Mudit; Amal Kaddoumi; Khalid A El Sayed
Journal:  Bioorg Med Chem       Date:  2009-06-27       Impact factor: 3.641
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