| Literature DB >> 11266153 |
G Nam1, C M Yoon, E Kim, C K Rhee, J H Kim, J H Shin, S H Kim.
Abstract
The syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 51 and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA).Entities:
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Year: 2001 PMID： 11266153 DOI： 10.1016/s0960-894x(00)00681-8
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823