Literature DB >> 11264391

Langat virus M protein is structurally homologous to prM.

M R Holbrook1, H Wang, A D Barrett.   

Abstract

Langat (LGT) virus M protein has been generated in a recombinant system. Antiserum raised against the LGT virus M protein neutralizes tick-borne encephalitis serocomplex flaviviruses but not mosquito-borne flaviviruses, indicating that the M protein is exposed on the surface of virions. The antiserum recognizes intracellular LGT virus prM/M and binds to prM and M in Western blots of whole-cell lysates and purified virus, respectively. These data suggest that the prM and M proteins are structurally similar under native conditions and support the hypothesis that the "pr" portion of prM facilitates proper folding of the M protein for expression on the virion surface.

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Year:  2001        PMID： 11264391      PMCID： PMC114893          DOI： 10.1128/JVI.75.8.3999-4001.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  8 in total

1.  Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E.

Authors:  S L Allison; K Stiasny; K Stadler; C W Mandl; F X Heinz
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

2.  Monoclonal antibodies for dengue virus prM glycoprotein protect mice against lethal dengue infection.

Authors:  B M Kaufman; P L Summers; D R Dubois; W H Cohen; M K Gentry; R L Timchak; D S Burke; K H Eckels
Journal:  Am J Trop Med Hyg       Date:  1989-11       Impact factor: 2.345

3.  Proteolytic activation of tick-borne encephalitis virus by furin.

Authors:  K Stadler; S L Allison; J Schalich; F X Heinz
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

4.  The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution.

Authors:  F A Rey; F X Heinz; C Mandl; C Kunz; S C Harrison
Journal:  Nature       Date:  1995-05-25       Impact factor: 49.962

5.  Synthesis and secretion of recombinant tick-borne encephalitis virus protein E in soluble and particulate form.

Authors:  S L Allison; K Stadler; C W Mandl; C Kunz; F X Heinz
Journal:  J Virol       Date:  1995-09       Impact factor: 5.103

6.  Structural changes and functional control of the tick-borne encephalitis virus glycoprotein E by the heterodimeric association with protein prM.

Authors:  F X Heinz; K Stiasny; G Püschner-Auer; H Holzmann; S L Allison; C W Mandl; C Kunz
Journal:  Virology       Date:  1994-01       Impact factor: 3.616

7.  Biological activities of the structural proteins of Japanese encephalitis virus.

Authors:  T Takegami; H Miyamoto; H Nakamura; K Yasui
Journal:  Acta Virol       Date:  1982-09       Impact factor: 1.162

8.  Proper maturation of the Japanese encephalitis virus envelope glycoprotein requires cosynthesis with the premembrane protein.

Authors:  E Konishi; P W Mason
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103
  8 in total

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