| Literature DB >> 11263924 |
H Ooi1, A Urushibara, T Esumi, Y Iwabuchi, S Hatakeyama.
Abstract
Reaction of (S)-2-(tert-butyldiphenylsilyloxy)-5-(mesyloxy)pentanal with hydroxylamine in allyl alcohol brought about simultaneous 1,3-dipolar cycloaddition of the resulting nitrone to allyl alcohol to give three diastereoisomeric adducts, from which (+)-febrifugine and (+)-isofebrifugine, potent antimalarial alkaloids, were synthesized.Entities:
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Year: 2001 PMID： 11263924 DOI： 10.1021/ol015655z
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005