Literature DB >> 11263875

Model studies for molecular recognition of carbonic anhydrase and carboxypeptidase.

E Kimura1.   

Abstract

Model studies using Zn(2+) complexes of various derivatives of macrocyclic triamines ([12]aneN(3)) and tetraamines (cyclen) have been found to be useful in elucidating and understanding the intrinsic properties of substrate or inhibitor recognition by zinc ions at the active centers of carbonic anhydrase and carboxypeptidase.

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Year:  2001        PMID： 11263875     DOI： 10.1021/ar000001w

Source DB:  PubMed          Journal:  Acc Chem Res        ISSN： 0001-4842            Impact factor:   22.384


  6 in total

Review 1.  Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding.

Authors:  Vijay M Krishnamurthy; George K Kaufman; Adam R Urbach; Irina Gitlin; Katherine L Gudiksen; Douglas B Weibel; George M Whitesides
Journal:  Chem Rev       Date:  2008-03       Impact factor: 60.622

2.  Study of the chelating properties of Ge(OH)2 functionality as metal binding group for Zn2+ cation in simplified protease-like environments: a DFT analysis.

Authors:  Pilar Gema Rodríguez Ortega; Manuel Montejo; Juan Jesús López González
Journal:  J Mol Model       Date:  2014-08-22       Impact factor: 1.810

3.  New supramolecular trigonal prisms from zinc(II)- 1,4,7,10-tetraazacyclododecane (cyclen) complexes and trithiocyanurate in aqueous solution.

Authors:  Shin Aoki; Mohd Zulkefeli; Motoo Shiro; Eiichi Kimura
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

4.  Flexibility of Catalytic Zinc Coordination in Thermolysin and HDAC8: A Born-Oppenheimer ab initio QM/MM Molecular Dynamics Study.

Authors:  Ruibo Wu; Po Hu; Shenglong Wang; Zexing Cao; Yingkai Zhang
Journal:  J Chem Theory Comput       Date:  2009-12-02       Impact factor: 6.006

5.  Synthesis and antimalarial activities of cyclen 4-aminoquinoline analogs.

Authors:  M O Faruk Khan; Mark S Levi; Babu L Tekwani; Shabana I Khan; Eiichi Kimura; Ronald F Borne
Journal:  Antimicrob Agents Chemother       Date:  2009-01-26       Impact factor: 5.191

6.  The zinc complex catalyzed hydration of alkyl isothiocyanates.

Authors:  Wilhelm A Eger; Burkhard O Jahn; Ernst Anders
Journal:  J Mol Model       Date:  2008-12-16       Impact factor: 1.810
  6 in total

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