Y Nakai1, T Koh. 1. College of Medical Technology, Kyoto University, 53 Kawaha-racho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.
Abstract
OBJECTIVE: We studied the effect of insulin-induced hypoglycemia on changes of hunger ratings in anorectic patients before and after cognitive-behavioral therapy. METHOD: The subjects were 17 females with restricting anorexia nervosa at low body weight (AN-R), 6 anorectic patients whose weight was restored after cognitive-behavioral therapy (AN-T), and 11 age-matched female controls. All subjects gave hunger ratings by linear visual analog technique before and after insulin or saline injection. RESULTS: Hunger ratings increased significantly 45 min after insulin injection in control females. However, ratings paradoxically decreased after insulin injection in AN-R females. They increased slightly after insulin injection in AN-T females, but the difference was not statistically significant. One-factor analysis of variance for the peak values of hunger ratings was significant. These values in control females were significantly higher than those in AN-R and AN-T females. DISCUSSION: These results suggest that perception of hunger to insulin-induced hypoglycemia in AN patients is disturbed. Copyright 2001 by John Wiley & Sons, Inc.
OBJECTIVE: We studied the effect of insulin-induced hypoglycemia on changes of hunger ratings in anorectic patients before and after cognitive-behavioral therapy. METHOD: The subjects were 17 females with restricting anorexia nervosa at low body weight (AN-R), 6 anorectic patients whose weight was restored after cognitive-behavioral therapy (AN-T), and 11 age-matched female controls. All subjects gave hunger ratings by linear visual analog technique before and after insulin or saline injection. RESULTS: Hunger ratings increased significantly 45 min after insulin injection in control females. However, ratings paradoxically decreased after insulin injection in AN-R females. They increased slightly after insulin injection in AN-T females, but the difference was not statistically significant. One-factor analysis of variance for the peak values of hunger ratings was significant. These values in control females were significantly higher than those in AN-R and AN-T females. DISCUSSION: These results suggest that perception of hunger to insulin-induced hypoglycemia in AN patients is disturbed. Copyright 2001 by John Wiley & Sons, Inc.
Authors: Irina A Strigo; Scott C Matthews; Alan N Simmons; Tyson Oberndorfer; Megan Klabunde; Lindsay E Reinhardt; Walter H Kaye Journal: Int J Eat Disord Date: 2012-07-27 Impact factor: 4.861