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Literature DB >> 11262225

The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development.

B Kerber¹, I Monge, M Mueller, P J Mitchell, S M Cohen.

Abstract

Flies mutant for the Drosophila homologue of the mammalian transcription factor AP-2 show a severe reduction in leg length and fail to develop joint structures. Presumptive joint cells express dAP-2 in response to Notch signaling. dAP-2 is required for joint cell differentiation and can induce formation of supernumerary joints when misexpressed. Although dAP-2 is expressed only in presumptive joint cells, its activity is required to support cell survival in the entire leg segment. Taken together, our data indicate that dAP-2 is an important mediator of Notch activity in leg development.

Entities: Chemical

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Year: 2001 PMID： 11262225 DOI： 10.1242/dev.128.8.1231

Source DB: PubMed Journal: Development ISSN： 0950-1991 Impact factor: 6.868

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Cited

16 in total

1. Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation.

Authors: F Zhao; C G Weismann; M Satoda; M E Pierpont; E Sweeney; E M Thompson; B D Gelb
Journal: Am J Hum Genet Date: 2001-08-14 Impact factor: 11.025

Review 2. A dynamic network of morphogens and transcription factors patterns the fly leg.

Authors: Carlos Estella; Roumen Voutev; Richard S Mann
Journal: Curr Top Dev Biol Date: 2012 Impact factor: 4.897

3. Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme.

Authors: Weiguo Feng; Jian Huang; Jian Zhang; Trevor Williams
Journal: Mol Cell Biol Date: 2007-11-05 Impact factor: 4.272

4. Essential roles for lines in mediating leg and antennal proximodistal patterning and generating a stable Notch signaling interface at segment borders.

Authors: Lina Greenberg; Victor Hatini
Journal: Dev Biol Date: 2009-03-24 Impact factor: 3.582

5. Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development.

Authors: Youngwook Ahn; Jizhong Zou; Pamela J Mitchell
Journal: Dev Biol Date: 2011-05-07 Impact factor: 3.582

6. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis.

Authors: Lina Greenberg; Victor Hatini
Journal: Mech Dev Date: 2010-09-17 Impact factor: 1.882

The AP-2 transcription factor is required for joint formation and cell survival in Drosophila leg development.

1. Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation.

Review 2. A dynamic network of morphogens and transcription factors patterns the fly leg.

3. Identification and analysis of a conserved Tcfap2a intronic enhancer element required for expression in facial and limb bud mesenchyme.

4. Essential roles for lines in mediating leg and antennal proximodistal patterning and generating a stable Notch signaling interface at segment borders.

5. Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development.

6. Systematic expression and loss-of-function analysis defines spatially restricted requirements for Drosophila RhoGEFs and RhoGAPs in leg morphogenesis.

7. Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor.

8. Tfap2a is a novel gatekeeper of nephron differentiation during kidney development.

Review 9. The AP-2 family of transcription factors.

10. AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.