Literature DB >> 11260800

Prion protein interconversions.

B Caughey1.   

Abstract

The transmissible spongiform encephalopathies (TSEs), or prion diseases, remain mysterious neurodegenerative diseases that involve perturbations in prion protein (PrP) structure. This article summarizes our use of in vitro models to describe how PrP is converted to the disease-associated, protease-resistant form. These models reflect many important biological parameters of TSE diseases and have been used to identify inhibitors of the PrP conversion as lead compounds in the development of anti-TSE drugs.

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Year:  2001        PMID： 11260800      PMCID： PMC1088425          DOI： 10.1098/rstb.2000.0765

Source DB:  PubMed          Journal:  Philos Trans R Soc Lond B Biol Sci        ISSN： 0962-8436            Impact factor:   6.237


  8 in total

1.  Simulations of oligomeric intermediates in prion diseases.

Authors:  David L Mobley; Daniel L Cox; Rajiv R P Singh; Rahul V Kulkarni; Alexander Slepoy
Journal:  Biophys J       Date:  2003-10       Impact factor: 4.033

Review 2.  Genes and proteins: dogmas in decline.

Authors:  Stuart A Newman; Ramray Bhat
Journal:  J Biosci       Date:  2007-09       Impact factor: 1.826

3.  Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions.

Authors:  Qiuye Li; Fei Wang; Xiangzhu Xiao; Chae Kim; Jen Bohon; Janna Kiselar; Jiri G Safar; Jiyan Ma; Witold K Surewicz
Journal:  J Biol Chem       Date:  2018-10-01       Impact factor: 5.157

4.  Chronic wasting disease of deer and elk in transgenic mice: oral transmission and pathobiology.

Authors:  Matthew J Trifilo; Ge Ying; Chao Teng; Michael B A Oldstone
Journal:  Virology       Date:  2007-04-23       Impact factor: 3.616

5.  The role of glycophosphatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro.

Authors:  Jae-Il Kim; Krystyna Surewicz; Pierluigi Gambetti; Witold K Surewicz
Journal:  FEBS Lett       Date:  2009-10-23       Impact factor: 4.124

6.  Recombinant human prion protein inhibits prion propagation in vitro.

Authors:  Jue Yuan; Yi-An Zhan; Romany Abskharon; Xiangzhu Xiao; Manuel Camacho Martinez; Xiaochen Zhou; Geoff Kneale; Jacqueline Mikol; Sylvain Lehmann; Witold K Surewicz; Joaquín Castilla; Jan Steyaert; Shulin Zhang; Qingzhong Kong; Robert B Petersen; Alexandre Wohlkonig; Wen-Quan Zou
Journal:  Sci Rep       Date:  2013-10-09       Impact factor: 4.379

7.  The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core.

Authors:  Irantzu Pallarès; Valentin Iglesias; Salvador Ventura
Journal:  Front Microbiol       Date:  2016-01-07       Impact factor: 5.640

8.  Mammalian prion protein (PrP) forms conformationally different amyloid intracellular aggregates in bacteria.

Authors:  Bruno Macedo; Ricardo Sant'Anna; Susanna Navarro; Yraima Cordeiro; Salvador Ventura
Journal:  Microb Cell Fact       Date:  2015-11-04       Impact factor: 5.328
  8 in total

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