| Literature DB >> 11260666 |
H B Patrzyc1, J B Dawidzik, E E Budzinski, H Iijima, H C Box.
Abstract
It was demonstrated previously that double lesions are produced in DNA by ionizing radiation. These double lesions consist of adjacent nucleotides each bearing a modified base. The goal of the present investigation was to determine whether Fenton chemistry can generate the same kind of lesions. DNA oligomers were exposed to metal-catalyzed H(2)O(2) reactions, and the products were characterized by chromatography and by mass spectrometry. Double lesions are produced by this treatment in which deoxyguanosine is oxidized to 8-oxo-7,8-dihydrodeoxyguanosine and an adjacent pyrimidine nucleoside is degraded to a formamido remnant.Entities:
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Year: 2001 PMID： 11260666 DOI： 10.1667/0033-7587(2001)155[0634:dlapid]2.0.co;2
Source DB: PubMed Journal: Radiat Res ISSN： 0033-7587 Impact factor: 2.841