D W Kaufman1, J P Kelly. 1. The Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MA 02446, USA.
Abstract
AIMS: Various nonsteroidal anti-inflammatory drugs are known to increase the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis. The relationship between salicylate treatment and these conditions is not known. METHODS: A case-control study was conducted in four countries in Europe from 1989 to 1995. RESULTS: Among 373 cases and 1720 controls, the multivariate relative risk estimate for any salicylate use in the previous week was 1.3 (95% confidence interval, 0.8-2.2); no statistically significant elevations were observed for single ingredient preparations or for salicylate-containing combination products. CONCLUSIONS: Acetylsalicylic acid and other salicylates are not associated with a measurable increase in the risk of these rare but severe reactions.
AIMS: Various nonsteroidal anti-inflammatory drugs are known to increase the risk of Stevens-Johnson syndrome and toxic epidermal necrolysis. The relationship between salicylate treatment and these conditions is not known. METHODS: A case-control study was conducted in four countries in Europe from 1989 to 1995. RESULTS: Among 373 cases and 1720 controls, the multivariate relative risk estimate for any salicylate use in the previous week was 1.3 (95% confidence interval, 0.8-2.2); no statistically significant elevations were observed for single ingredient preparations or for salicylate-containing combination products. CONCLUSIONS:Acetylsalicylic acid and other salicylates are not associated with a measurable increase in the risk of these rare but severe reactions.
Authors: J C Roujeau; J P Kelly; L Naldi; B Rzany; R S Stern; T Anderson; A Auquier; S Bastuji-Garin; O Correia; F Locati Journal: N Engl J Med Date: 1995-12-14 Impact factor: 91.245
Authors: J P Kelly; A Auquier; B Rzany; L Naldi; S Bastuji-Garin; O Correia; S Shapiro; D W Kaufman Journal: J Clin Epidemiol Date: 1995-09 Impact factor: 6.437