| Literature DB >> 11259788 |
V Jevtovic-Todorovic1, D F Wozniak, N D Benshoff, J W Olney.
Abstract
The general anesthetics, nitrous oxide (N(2)O) and ketamine, are NMDA antagonists which, like other NMDA antagonists such as MK801, induce a neurotoxic reaction in the rat brain. For MK801 neurotoxicity, both age and sex are important variables (adult rats are more sensitive than immature rats and females are more sensitive than males). In this study we found that ketamine has this same age and sex dependency profile, and N(2)O has the same age but not sex dependency. Male and female rats are equally sensitive to N(2)O neurotoxicity.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11259788 DOI： 10.1016/s0006-8993(01)02079-0
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252