Literature DB >> 11259064

An efficient synthesis of 3-hetero-13,14-dihydro prostaglandin F1alpha analogues.

J Gu1, M J Dirr, Y Wang, D L Soper, B De, J A Wos, C R Johnson.   

Abstract

[structure: see text]. A new class of 3-hetero-13,14-dihydro prostaglandin F(1)(alpha) analogues was synthesized from a common intermediate. The latter was constructed via a two-step, three-component process. The lower chain, containing the 15-(phenoxymethyl) group, was synthesized in enantiopure form using Jacobsen's (salen)Co-catalyzed kinetic resolution of a terminal epoxide with phenol.

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Year:  2001        PMID: 11259064     DOI: 10.1021/ol015613a

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  1 in total

1.  Synthesis of tetranor-PGE1: a urinary metabolite of prostaglandins E1 and E2.

Authors:  Jennifer R Kimbrough; Somnath Jana; Kwangho Kim; Alexander Allweil; John A Oates; Ginger L Milne; Gary A Sulikowski
Journal:  Tetrahedron Lett       Date:  2020-04-10       Impact factor: 2.415

  1 in total

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