Literature DB >> 11257581

In vivo pharmacokinetics and pharmacodynamics in drug development using positron-emission tomography.

E O. Aboagye1, P M. Price, T Jones.   

Abstract

Positron-emission tomography (PET) is a sensitive technique that can be used to measure drug pharmacokinetics and pharmacodynamics non-invasively in target tissues of patients. Here we focus on the application of this technology to address some of the bottlenecks in drug development, including: elucidation of pathophysiology, evaluation of pharmacokinetics, proof of principle of mechanism, and assessment of efficacy and/or response to therapy.

Entities:  

Year:  2001        PMID： 11257581     DOI： 10.1016/s1359-6446(01)01684-1

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  23 in total

1.  In vivo biodistribution and pharmacokinetics of 18F-labelled Spiegelmers: a new class of oligonucleotidic radiopharmaceuticals.

Authors:  Raphaël Boisgard; Bertrand Kuhnast; Stefan Vonhoff; Chéraz Younes; Françoise Hinnen; Jean-Marc Verbavatz; Bernard Rousseau; Jens Peter Fürste; Britta Wlotzka; Frédéric Dollé; Sven Klussmann; Bertrand Tavitian
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-12-22       Impact factor: 9.236

2.  The phase 0 microdosing concept.

Authors:  R Colin Garner; Graham Lappin
Journal:  Br J Clin Pharmacol       Date:  2006-04       Impact factor: 4.335

3.  Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.

Authors:  Jeffrey S Stehouwer; Nachwa Jarkas; Fanxing Zeng; Ronald J Voll; Larry Williams; Vernon M Camp; Eugene J Malveaux; John R Votaw; Leonard Howell; Michael J Owens; Mark M Goodman
Journal:  J Med Chem       Date:  2008-12-25       Impact factor: 7.446

Review 4.  In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches.

Authors:  Ben Forbes; Per Bäckman; David Christopher; Myrna Dolovich; Bing V Li; Beth Morgan
Journal:  AAPS J       Date:  2015-05-05       Impact factor: 4.009

5.  Radiosynthesis and PET Bioimaging of 76Br-Bedaquiline in a Murine Model of Tuberculosis.

Authors:  Alvaro A Ordonez; Laurence S Carroll; Sudhanshu Abhishek; Filipa Mota; Camilo A Ruiz-Bedoya; Mariah H Klunk; Alok K Singh; Joel S Freundlich; Ronnie C Mease; Sanjay K Jain
Journal:  ACS Infect Dis       Date:  2019-07-29       Impact factor: 5.084

6.  Automatic concentration and reformulation of PET tracers via microfluidic membrane distillation.

Authors:  Philip H Chao; Jeffery Collins; Joseph P Argus; Wei-Yu Tseng; Jason T Lee; R Michael van Dam
Journal:  Lab Chip       Date:  2017-05-16       Impact factor: 6.799

7.  Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.

Authors:  Jeffrey S Stehouwer; Mark M Goodman
Journal:  PET Clin       Date:  2009-01

8.  Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.

Authors:  Jeffrey S Stehouwer; Matthew S Birnbaum; Ronald J Voll; Michael J Owens; Susan J Plott; Chase H Bourke; Michael A Wassef; Clinton D Kilts; Mark M Goodman
Journal:  Bioorg Med Chem       Date:  2015-06-19       Impact factor: 3.641

9.  Food and drug administration's critical path initiative and innovations in drug development paradigm: Challenges, progress, and controversies.

Authors:  Rajiv Mahajan; Kapil Gupta
Journal:  J Pharm Bioallied Sci       Date:  2010-10

Review 10.  In vivo imaging with oligonucleotides for diagnosis and drug development.

Authors:  B Tavitian
Journal:  Gut       Date:  2003-06       Impact factor: 23.059
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