| Literature DB >> 11257338 |
E G Saravolac1, D Sabuda, C Crist, K Blasetti, G Schnell, H Yang, M Kende, H B Levy, J P Wong.
Abstract
The objective of this report is to evaluate the prophylactic efficacy of liposome-mediated immunotherapy for prevention of respiratory influenza virus infection in mice. Antiviral antibody, interferon-gamma and poly (ICLC) were encapsulated in liposomes and they were evaluated for their ability to induce protective immunity against lethal influenza infection. Passive immunization using liposome-encapsulated antiviral antibody was found to offer complete protection against the virus challenge. However, this pretreatment must be administered within 24 h prior to virus challenge to be protective. Pretreatment with liposome-encapsulated interferon-gamma was found to stimulate cellular immune responses, but the protection is partial. Immunoprophylaxis using liposome-encapsulated double-stranded (ds) RNA poly (ICLC) provided complete and longer-lasting protection against influenza infection. These results suggest liposome-mediated immunoprophylactic approaches are effective in the prevention of respiratory influenza virus infection.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11257338 DOI： 10.1016/s0264-410x(00)00450-3
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641