Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: potential surrogate marker in tuberculosis chemotherapy trials.

Literature DB >> 11257053

Inhibition of isoniazid-induced expression of Mycobacterium tuberculosis antigen 85 in sputum: potential surrogate marker in tuberculosis chemotherapy trials.

R S Wallis¹, M Phillips, J L Johnson, L Teixeira, L M Rocha, E Maciel, L Rose, C Wells, M Palaci, R Dietze, K Eisenach, J J Ellner.

Abstract

Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2001 PMID： 11257053 PMCID： PMC90462 DOI： 10.1128/AAC.45.4.1302-1304.2001

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

1. The early bactericidal activity of isoniazid related to its dose size in pulmonary tuberculosis.

Authors: P R Donald; F A Sirgel; F J Botha; H I Seifart; D P Parkin; M L Vandenplas; B W Van de Wal; J S Maritz; D A Mitchison
Journal: Am J Respir Crit Care Med Date: 1997-09 Impact factor: 21.405

2. Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis.

Authors: D A Mitchison; A J Nunn
Journal: Am Rev Respir Dis Date: 1986-03

3. Induction of the antigen 85 complex of Mycobacterium tuberculosis in sputum: a determinant of outcome in pulmonary tuberculosis treatment.

Authors: R S Wallis; M Perkins; M Phillips; M Joloba; B Demchuk; A Namale; J L Johnson; D Williams; K Wolski; L Teixeira; R Dietze; R D Mugerwa; K Eisenach; J J Ellner
Journal: J Infect Dis Date: 1998-10 Impact factor: 5.226

4. The action of antituberculosis drugs in short-course chemotherapy.

Authors: D A Mitchison
Journal: Tubercle Date: 1985-09

5. Isoniazid induces expression of the antigen 85 complex in Mycobacterium tuberculosis.

Authors: T R Garbe; N S Hibler; V Deretic
Journal: Antimicrob Agents Chemother Date: 1996-07 Impact factor: 5.191

6. Predicting the outcome of therapy for pulmonary tuberculosis.

Authors: R S Wallis; M D Perkins; M Phillips; M Joloba; A Namale; J L Johnson; C C Whalen; L Teixeira; B Demchuk; R Dietze; R D Mugerwa; K Eisenach; J J Ellner
Journal: Am J Respir Crit Care Med Date: 2000-04 Impact factor: 21.405

7. The early bactericidal activity of rifabutin in patients with pulmonary tuberculosis measured by sputum viable counts: a new method of drug assessment.

Authors: F A Sirgel; F J Botha; D P Parkin; B W Van De Wal; P R Donald; P K Clark; D A Mitchison
Journal: J Antimicrob Chemother Date: 1993-12 Impact factor: 5.790

8. Early bactericidal activity of ethambutol, pyrazinamide and the fixed combination of isoniazid, rifampicin and pyrazinamide (Rifater) in patients with pulmonary tuberculosis.

Authors: F J Botha; F A Sirgel; D P Parkin; B W van de Wal; P R Donald; D A Mitchison
Journal: S Afr Med J Date: 1996-02

8 in total

4 in total

1. Isoniazid Monoresistance and Rate of Culture Conversion among Patients in the State of Georgia with Confirmed Tuberculosis, 2009-2014.

Authors: Argita D Salindri; Rose-Marie F Sales; Lauren DiMiceli; Marcos C Schechter; Russell R Kempker; Matthew J Magee
Journal: Ann Am Thorac Soc Date: 2018-03