Literature DB >> 11255897

Symptoms, signs, and prescribing for acute lower respiratory tract illness.

W F Holmes1, J T Macfarlane, R M Macfarlane, R Hubbard.   

Abstract

BACKGROUND: Most patients who consult with acute lower respiratory symptoms receive antibiotics, usually without evidence of significant infection. The physical signs at presentation of acute lower respiratory tract illness and the rate at which symptoms resolve and normal activities recover is not well documented. AIM: To examine in patients with lower respiratory tract infection (LRTi), their physical signs at presentation, their relationship to antibiotic prescribing, and symptom resolution and resumption of normal activities. DESIGN OF STUDY: Analysis of data collected prospectively during presentation of acute LRTi in primary care and from patient symptom diary cards.
SETTING: Forty GPs who were members of an informal Community Respiratory Infection Interest Group recruited 391 patients to the study.
METHOD: Information was collected on pulse, oral temperature, respiratory rate, abnormalities on auscultation, and details of any antibiotic prescription. Patients completed symptom diary cards for the following 10 days.
RESULTS: Of the 391 patients who consulted 71% received antibiotics. A minority had abnormal physical signs: 17% had a pulse greater than 90 bpm, 15% a respiratory rate greater than 20 breaths per minute, 4% had a temperature greater than 38 degrees C, and 25% had an abnormality on auscultation. Antibiotic prescribing was more common in the presence of abnormal chest signs (odds ratio = 8.71, 95% confidence interval = 3.69-20.61) or discoloured sputum (OR = 2.67, 95% CI = 1.57-4.56). Ten days after consultation, 58% of patients were still coughing and 29% had not returned to normal activities.
CONCLUSION: Abnormal physical signs at presentation do not explain the high rates of antibiotic prescribing nor do they predict persisting cough and functional impairment at 10 days. Reconsultation for the same symptoms within a month is common and is strongly related to persisting cough, but not abnormalities at presentation.

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Year:  2001        PMID: 11255897      PMCID: PMC1313947     

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  19 in total

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Authors:  J Macfarlane; W F Holmes; R Macfarlane
Journal:  Thorax       Date:  2000-02       Impact factor: 9.139

2.  A study of the relationship between patients' attitudes and doctors' prescribing.

Authors:  A Virji; N Britten
Journal:  Fam Pract       Date:  1991-12       Impact factor: 2.267

Review 3.  Lower respiratory tract infection and pneumonia in the community.

Authors:  J Macfarlane
Journal:  Semin Respir Infect       Date:  1999-06

4.  Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community.

Authors:  J Macfarlane; W Holmes; P Gard; R Macfarlane; D Rose; V Weston; M Leinonen; P Saikku; S Myint
Journal:  Thorax       Date:  2001-02       Impact factor: 9.139

5.  What will it take to stop physicians from prescribing antibiotics in acute bronchitis?

Authors:  R Gonzales; M Sande
Journal:  Lancet       Date:  1995-03-18       Impact factor: 79.321

6.  Factors associated with antibiotic use for acute bronchitis.

Authors:  R Gonzales; P H Barrett; L A Crane; J F Steiner
Journal:  J Gen Intern Med       Date:  1998-08       Impact factor: 5.128

7.  A randomized, controlled trial of doxycycline in the treatment of acute bronchitis.

Authors:  H A Williamson
Journal:  J Fam Pract       Date:  1984-10       Impact factor: 0.493

Review 8.  Randomized placebo-controlled trials of antibiotics for acute bronchitis: a critical review of the literature.

Authors:  P H Orr; K Scherer; A Macdonald; M E Moffatt
Journal:  J Fam Pract       Date:  1993-05       Impact factor: 0.493

9.  Acute bronchitis: course of symptoms and restrictions in patients' daily activities.

Authors:  T Verheij; J Hermans; A Kaptein; J Mulder
Journal:  Scand J Prim Health Care       Date:  1995-03       Impact factor: 2.581

10.  Repeat consultations after antibiotic prescribing for respiratory infection: a study in one general practice.

Authors:  P Davey; D Rutherford; B Graham; B Lynch; M Malek
Journal:  Br J Gen Pract       Date:  1994-11       Impact factor: 5.386

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  25 in total

1.  A wake up call for primary care.

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Journal:  Br J Gen Pract       Date:  2002-11       Impact factor: 5.386

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3.  Diagnosing coughs and colds.

Authors:  Jenny Doust; Chris Del Mar
Journal:  Br J Gen Pract       Date:  2004-01       Impact factor: 5.386

4.  A diagnostic rule for the aetiology of lower respiratory tract infections as guidance for antimicrobial treatment.

Authors:  A Willy Graffelman; Arie Knuistingh Neven; Saskia le Cessie; Aloys C M Kroes; Machiel P Springer; Peterhans J van den Broek
Journal:  Br J Gen Pract       Date:  2004-01       Impact factor: 5.386

5.  Pathogens involved in lower respiratory tract infections in general practice.

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6.  Is dyspraxia a medical condition or a social disorder?

Authors:  Amanda Kirby
Journal:  Br J Gen Pract       Date:  2004-01       Impact factor: 5.386

7.  Predicting complications from acute cough in pre-school children in primary care: a prospective cohort study.

Authors:  Alastair D Hay; Tom Fahey; Tim J Peters; Andrew Wilson
Journal:  Br J Gen Pract       Date:  2004-01       Impact factor: 5.386

8.  SAPC: scotching the myths.

Authors:  Blair H Smith; Adrian Edwards; Peter Murchie
Journal:  Br J Gen Pract       Date:  2005-04       Impact factor: 5.386

Review 9.  Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review.

Authors:  Victor van der Meer; Arie Knuistingh Neven; Peterhans J van den Broek; Willem J J Assendelft
Journal:  BMJ       Date:  2005-06-24

10.  Antibiotic prescribing for acute cough: the effect of perceived patient demand.

Authors:  Samuel Coenen; Barbara Michiels; Didier Renard; Joke Denekens; Paul Van Royen
Journal:  Br J Gen Pract       Date:  2006-03       Impact factor: 5.386

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