A Chacko1, R Koul, D K Sankhla. 1. Division of Pediatric Neurology, Deparment of Child Health, Sultan Qaboos University Hospital, PO Box 35, Postal Code 123, Sultanate of Oman.
Abstract
OBJECTIVE: The objectives are to analyse corpus callosum agenesis in children with various neurological problems in a hospital set-up, and to study the neurological and systemic abnormalities associated with this condition. METHODS: The children with various neurological problems who underwent computerized tomography brain from January 1993 to December 1997, and were found to have corpus callosum agenesis, formed the subjects of this study. These children were examined for any syndromic association, congenital infections or metabolic defects. RESULTS: Out of 2164 children who underwent computerized tomography brain, 22 had corpus callosum agenesis (1%). Most cases were not syndromic and 64% were males. Epileptic disorders were noted in about one third of cases. CONCLUSION: Corpus callosum agenesis is an important anomaly in children with neurodevelopment handicaps, usually detected by neuroradiology.
OBJECTIVE: The objectives are to analyse corpus callosum agenesis in children with various neurological problems in a hospital set-up, and to study the neurological and systemic abnormalities associated with this condition. METHODS: The children with various neurological problems who underwent computerized tomography brain from January 1993 to December 1997, and were found to have corpus callosum agenesis, formed the subjects of this study. These children were examined for any syndromic association, congenital infections or metabolic defects. RESULTS: Out of 2164 children who underwent computerized tomography brain, 22 had corpus callosum agenesis (1%). Most cases were not syndromic and 64% were males. Epileptic disorders were noted in about one third of cases. CONCLUSION: Corpus callosum agenesis is an important anomaly in children with neurodevelopment handicaps, usually detected by neuroradiology.
Authors: R M Hanna; S E Marsh; D Swistun; L Al-Gazali; M S Zaki; G M Abdel-Salam; A Al-Tawari; L Bastaki; H Kayserili; A Rajab; B Boglárka; R B Dietrich; W B Dobyns; C L Truwit; S Sattar; N A Chuang; E H Sherr; J G Gleeson Journal: Neurology Date: 2011-01-25 Impact factor: 11.800